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Two case reports of MDA5-type seronegative dermatomyositis.
SAGE Open Med Case Rep
December 2024
Division of Dermatology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Dermatomyositis (DM) is an autoimmune idiopathic inflammatory myopathy with characteristic dermatologic manifestations. Myositis-specific autoantibodies (MSAs) delineate DM subtypes and their prognoses. Uncommonly, patients present with distinct clinical features of DM, including photosensitive dermatitis, heliotrope rash, Gottron's papules, and nailfold changes; however, their autoimmune serology is negative for expected MSAs.
View Article and Find Full Text PDFPhotosensitive dermatitis caused by nintedanib in a patient of chronic fibrosing interstitial lung disease already on pirfenidone.
Indian J Pharmacol
September 2024
Department of Dermatology, Government Medical College, Patiala, Punjab, India.
An In Vitro Strategy to Evaluate Ketoprofen Phototoxicity at the Molecular and Cellular Levels.
Int J Mol Sci
November 2024
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 40-055 Katowice, Poland.
Article Synopsis
- Phototoxicity, a common issue linked to many medications including over-the-counter ones, highlights the importance of testing drugs for their potential to cause harm under UV light!
- This study focuses on the effects of ketoprofen on human skin cells, using various tests to analyze its cytotoxicity and phototoxicity under different treatment conditions!
- Findings revealed that ketoprofen poses the highest risk of phototoxic reactions when it is directly applied to cells during UV exposure, affecting both pigmented and non-pigmented skin cells!
Palmate Erythema With Pruritus Following Contact With Lime Juice, a Variant of "Margarita Photodermatitis".
Contact Dermatitis
December 2024
Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Topical Sunscreens: A Narrative Review for Contact Sensitivity, Potential Allergens, Clinical Evaluation, and Management for their Optimal Use in Clinical Practice.
Indian Dermatol Online J
October 2024
Department of Dermatology, Venereology and Leprosy, Dr. Radhakrishnan Government Medical College, Hamirpur, Himachal Pradesh, India.
Topical sunscreens decrease the quantity of ultraviolet (UV) light from the sun reaching the skin by either blocking or scattering it and help protect the skin from dyspigmentation, photoaging, DNA damage, and photocarcinogenesis, especially in photosensitive individuals. The significant role played by visible light and infrared light in skin pigmentation and photoaging has been recognized in recent years. The majority of broad-spectrum sunscreens protect against UV-B (290-320nm) and UV-A (320-400nm) radiation.
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