AI Article Synopsis
- Liposarcomas are the most common type of soft tissue sarcoma, primarily found in deep tissues and the retroperitoneum.
- They include various classifications such as atypical lipomatous tumors, well-differentiated liposarcoma (WDL), dedifferentiated liposarcoma (DDL), myxoid liposarcoma, and pleomorphic liposarcoma.
- DDL is especially common in the retroperitoneum and can have both well-differentiated lipomatous and dedifferentiated components, sometimes resembling other aggressive tumors, and can even differentiate into several other cancer types or form bone tissue.
Article Abstract
Liposarcomas are the most common soft tissue sarcoma primarily originating in deep soft tissues and the retroperitoneum. Sarcoma classification includes atypical lipomatous tumor/well-differentiated liposarcoma (WDL) and dedifferentiated liposarcoma (DDL), myxoid liposarcoma, and pleomorphic liposarcoma. DDL is most prevalent in the retroperitoneum and often has two distinct components, a well-differentiated lipomatous component and a dedifferentiated nonlipomatous component that could be morphologically similar to malignant fibrous histiocytoma (MFH) or fibrosarcoma. DDLs can undergo heterologous differentiation into multiple cancer types including rhabdomyosarcoma, chondrosarcoma, melanoma, and leiomyosarcoma. Rarely, DDLs can undergo metaplastic bone formation. We report a peculiar case of a DDL with an osseous component.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11647061 | PMC |
| http://dx.doi.org/10.7759/cureus.73735 | DOI Listing |
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