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| http://dx.doi.org/10.1016/j.omtn.2024.102384 | DOI Listing |
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Research and development of new intelligent foaming and discharging agent system.
Sci Rep
December 2024
Hubei Key Laboratory of Oil and Gas Drilling and Production Engineering, Yangtze University, Wuhan, 430100, China.
The application of classic foaming agent faces several issues, including excessive use of defoaming agent, inadequate defoaming, pipeline blockage due to silicone oil precipitation, and high development cost of the foaming agent. To address the aforementioned issues, a novel intelligent foaming agent was created. This resulted in the development of a new intelligent foaming and discharging agent system.
View Article and Find Full Text PDFOnco-mNGS facilitates rapid and precise identification of the etiology of fever of unknown origin: a single-centre prospective study in North China.
BMC Infect Dis
December 2024
Department of Infectious Diseases, The First Hospital of China Medical University, Shenyang, 110001, China.
Objectives: Delayed diagnosis of patients with Fever of Unknown Origin has long been a daunting clinical challenge. Onco-mNGS, which can accurately diagnose infectious agents and identify suspected tumor signatures by analyzing host chromosome copy number changes, has been widely used to assist identifying complex etiologies. However, the application of Onco-mNGS to improve FUO etiological screening has never been studied before.
View Article and Find Full Text PDFClinical Spectrum and Prognosis of Atypical Autosomal Dominant Polycystic Kidney Disease Caused by Monoallelic Pathogenic Variants of IFT140.
Am J Kidney Dis
December 2024
Service de Néphrologie, Hémodialyse et Transplantation Rénale, Centre de référence MARHEA, CHRU Brest, Brest, France; Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Brussels, Belgium. Electronic address:
Rationale & Objective: Monoallelic predicted Loss-of-Function (pLoF) variants in IFT140 have recently been associated with an autosomal dominant polycystic kidney disease (ADPKD)-like phenotype. This study sought to enhance the characterization of this phenotype.
Study Design: Case series.
Improved aquila optimizer for swarm-based solutions to complex engineering problems.
Sci Rep
December 2024
Department of Computer Science, College of Computer and Information Sciences, King Saud University, 11543, Riyadh, Saudi Arabia.
The traditional optimization approaches suffer from certain problems like getting stuck in local optima, low speed, susceptibility to local optima, and searching unknown search spaces, thus requiring reliance on single-based solutions. Herein, an Improved Aquila Optimizer (IAO) is proposed, which is a unique meta-heuristic optimization method motivated by the hunting behavior of Aquila. An improved version of Aquila optimizer seeks to increase effectiveness and productivity.
View Article and Find Full Text PDFTumor-targeted nanosystem with hypoxia inducible factor 1α inhibition for synergistic chemo-photodynamic therapy against hypoxic tumor.
Colloids Surf B Biointerfaces
December 2024
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; National Innovation Platform for medical industry-education integration, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address:
Photodynamic therapy (PDT) holds an essential role in the therapy of tumors. However, PDT consumes tissue oxygen and diminishes its own efficacy by inducing tumor hypoxia through the HIF-1α/VEGF pathway. Therefore, overcoming the photodynamic exacerbation of tumor hypoxia could reverse tumor microenvironment and enhance PDT.
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