Background And Objectives: A pathological increase in intestinal permeability causes muscle loss and physical decline by inducing systemic inflammation and oxidative stress. However, most relevant studies investigate older adults, and the appropriate data across age spans remain elusive. This study aimed to examine the associations of intestinal permeability with muscle loss and physical decline across a large span of ages. We measured plasma zonulin, a marker of increased intestinal permeability, from adolescents to octogenarians in association with muscle health and gait speed.

Research Methods And Procedures: In this cross-sectional, observational study, we recruited healthy men, including young (age=18-35 years, n=135), middle-aged (age=35-59 years, n=118), and older (age=60-90 years, n=163) adults for evaluating - handgrip strength (HGS), skeletal muscle mass index (SMI), and gait speed. We also measured plasma zonulin, c-reactive proteins (CRP), and 8-isoprostanes using ELISA assays.

Results: Plasma zonulin gradually increased from young and middle-aged to older adults (all p<0.05). Conversely, HGS and gait speed were progressively reduced from young and middle-aged to older adults (all p<0.05). In addition, older adults also exhibited lower SMI than young and middle-aged men (both p<0.05). Plasma zonulin exhibited significant negative correlations with HGS and gait speed and positive correlations with CRP and 8-isoprostanes in middle-aged and older men (all p<0.05). We also found significant areas under the curve for the efficacy of plasma zonulin in diagnosing low HGS (<27kg) and gait speed (0.8 m/s). After adjustment for age, plasma zonulin demonstrated robust negative correlations with HGS and gait speed and positive correlations with CRP and 8-isoprostanes in the cumulative cohort.

Conclusion: Altogether, an increasing intestinal leak from middle age onward contributes to muscle weakness and physical decline. Our data is clinically relevant in understanding and treating physical dependency in middle-aged and older adults.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11648551PMC
http://dx.doi.org/10.2147/IJGM.S501358DOI Listing

Publication Analysis

Top Keywords

muscle loss
12
loss physical
12
intestinal permeability
12
plasma zonulin
12
permeability muscle
8
physical decline
8
older adults
8
measured plasma
8
muscle
5
pathology intestinal
4

Similar Publications

Shared genetic architecture of type 2 diabetes with muscle mass and function and frailty reveals comorbidity etiology and pleiotropic druggable targets.

Metabolism

December 2024

Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Background: Delineating the shared genetic architecture of type 2 diabetes with muscle mass and function and frailty is essential for unraveling the common etiology and developing holistic therapeutic strategies for these co-existing conditions.

Methods: In this genome-wide pleiotropic association study, we performed multi-level pairwise trait pleiotropic analyses using genome-wide association study summary statistics from up to 461,026 European ancestry individuals to dissect the shared genetic factors and causal relationships of type 2 diabetes and seven glycemic traits with four muscle mass- and function-related phenotypes and the frailty index.

Results: We first identified 27 pairs with significant genetic correlations through the linkage disequilibrium score regression and high-definition likelihood analysis.

View Article and Find Full Text PDF

Aim: Idiopathic pulmonary fibrosis (IPF) is a debilitating and fatal lung disease. Changes in body composition potentially correlate with outcomes in patients with IPF.

Materials And Methods: Patients with IPF on antifibrotic treatment attending a single institution were identified and retrospectively evaluated (n=84).

View Article and Find Full Text PDF

Introduction And Importance: In Morocco, diagnosing Gamma Sarcoglycanopathies mainly relies on histopathological analysis of muscle biopsies due to limited genetic and molecular research access. This study highlights the significance of muscle biopsies and explores potential predictive factors and possible correlation between histopathological abnormalities and clinical phenotypes.

Case Presentation: Muscle biopsies of six patients diagnosed with γ-sarcoglycanopathy were collected over two years.

View Article and Find Full Text PDF

Electrical stimulation of injured nerves promotes recovery in animals and humans.

J Physiol

December 2024

Division of Reconstructive and Plastic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

The frequent poor functional outcomes after delayed surgical repair of injured human peripheral nerves results in progressive downregulation of growth-associated genes in parallel with reduced neuronal regenerative capacity under each of the experimental conditions of chronic axotomy of neurones that remain without target contact, chronic distal nerve stump denervation, and chronic muscle denervation. Brief (1 h) low-frequency (20 Hz) electrical stimulation (ES) accelerates the outgrowth of regenerating axons across the surgical site of microsurgical repair of a transected nerve. Exercise programmes also promote nerve regeneration with the combination of ES and exercise being the most effective.

View Article and Find Full Text PDF

Epigenetic regulation of vascular smooth muscle cell phenotypes in atherosclerosis.

Atherosclerosis

December 2024

Section of Cardiorespiratory Medicine, University of Cambridge, VPD Heart and Lung Research Institute, Papworth Road, Cambridge Biomedical Campus, Cambridge, CB2 0BB, UK. Electronic address:

Vascular smooth muscle cells (VSMCs) in adult arteries maintain substantial phenotypic plasticity, which allows for the reversible cell state changes that enable vascular remodelling and homeostasis. In atherosclerosis, VSMCs dedifferentiate in response to lipid accumulation and inflammation, resulting in loss of their characteristic contractile state. Recent studies showed that individual, pre-existing VSMCs expand clonally and can acquire many different phenotypes in atherosclerotic lesions.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!