AI Article Synopsis
- The study aimed to explore how serum osteocalcin levels relate to diabetic kidney disease (DKD) progression in Chinese individuals.
- Researchers reviewed 20 case-control studies, including over 4,500 participants, to analyze osteocalcin levels across different diabetes-related groups.
- Findings revealed that lower serum osteocalcin levels were linked to more severe proteinuria, suggesting a decline in bone formation as DKD progresses.
Article Abstract
Objective: To systemically assess the relationship between serum osteocalcin levels and the progression of diabetic kidney disease (DKD) in the Chinese population.
Methods: The PubMed, Web of Science, CNKI, Wanfang Database, VIP and Chinese Medical Journal full-text Database were searched. Two investigators independently reviewed the literature and extracted data based on predetermined inclusion and exclusion criteria. The Newcastle-Ottawa scale was used to assess the quality of the literature. The statistical analysis was performed using Stata16 software.
Results: A total of 20 case-control studies encompassed 4 565 cases, consisting of 643 healthy controls (CN), 1 649 individuals with simple diabetes mellitus (DM), 1 305 with microalbuminuria (MI), and 968 with macroalbuminuria (MA). The meta-analysis results indicated that the serum osteocalcin levels in MI group were significantly lower than those in CN group and DM group [SMD = -1.15, 95% CI (-1.46, -0.85), P < 0.01; and SMD = -0.53, 95% CI (-0.69, -0.37), P < 0.01, respectively], and lower in the MA group compared to the CN group [SMD = -1.28, 95% CI (-1.79, -0.76), P < 0.01]. In the MA group, the serum osteocalcin levels were considerably lower compared to those in DM group and MI group [SMD = -0.93, 95% CI (-1.28, -0.58), P < 0.01; and SMD = -0.41, 95% CI (-0.65, -0.17), P < 0.01, respectively].
Conclusion: The serum osteocalcin levels are typically reduced and show a negative correlation with the severity of proteinuria in Chinese patients with DKD. This indicates a decline in bone formation at early-stage in DKD patients, which worsens as the disease progresses.
Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/,identifier CRD42024580324.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646725 | PMC |
| http://dx.doi.org/10.3389/fendo.2024.1514713 | DOI Listing |
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Article Synopsis
- The study aimed to explore how serum osteocalcin levels relate to diabetic kidney disease (DKD) progression in Chinese individuals.
- Researchers reviewed 20 case-control studies, including over 4,500 participants, to analyze osteocalcin levels across different diabetes-related groups.
- Findings revealed that lower serum osteocalcin levels were linked to more severe proteinuria, suggesting a decline in bone formation as DKD progresses.
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