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| http://dx.doi.org/10.1111/irv.70055 | DOI Listing |
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Tocilizumab alleviated lipopolysaccharide-induced acute lung injury by improving PI3K/AKT pathway.
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Department of Clinical Medicine, Fujian Medical University, Fuzhou, 350000, China.
Acute lung injury (ALI) is a severe inflammatory condition of the respiratory system, associated with high morbidity and mortality. This study investigates the therapeutic potential of tocilizumab (TZ), an IL-6 receptor inhibitor, in mitigating lipopolysaccharide (LPS)-induced ALI by modulating the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway. An ALI model was established using LPS induction.
View Article and Find Full Text PDFValidation and the role of PDK4 relevant to ferroptosis in degenerative lumbar disc disease.
J Orthop Surg Res
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Department of Orthopaedics, Qilu Hospital of Shandong University, No.107, Wenhuaxi Road, Lixia District, Jinan, Shandong Province, 250012, China.
Background: Ferroptosis was involved in the pathogenesis of intervertebral disc degeneration (IVDD). However, the exact mechanism of IVDD associated with ferroptosis still required deeper studies.
Method: The differentially expressed genes (DEGs) in rat lumbar disc tissue between the control and IVDD group treated with IL-1β were detected by RNA sequencing (RNA-seq).
Emerging biofilm formation and disinfectant susceptibility of ESBL-producing Klebsiella pneumoniae.
Sci Rep
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Department of Zoonoses, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
Klebsiella pneumoniae is an opportunistic pathogen responsible for various infections in humans and animals. It is known for its resistance to multiple antibiotics, particularly through the production of Extended-Spectrum Beta-Lactamases (ESBLs), and its ability to form biofilms that further complicate treatment. This study aimed to isolate and identify K.
View Article and Find Full Text PDFGrey mullets (family Mugilidae) are widespread across coastal, brackish, and freshwater habitats, and have supported fisheries for millennia. Despite their global distribution and commercial value, little is known about their movement ecology and its role in the co-existence of sympatric mullet species. Gaps in knowledge about migratory behaviour, seasonal occurrence, and movement scales have also impeded effective management, highlighting the need for further research.
View Article and Find Full Text PDFThe influence of phosphoinositide lipids in the molecular biology of membrane proteins: recent insights from simulations.
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Institute of Biological Chemistry, Academia Sinica, Taipei 115 Taiwan; Department of Chemistry, University of Oxford, South Parks Road, Oxford OX1 3QZ UK.
The phosphoinositide family of membrane lipids play diverse and critical roles in eukaryotic molecular biology. Much of this biological activity derives from interactions of phosphoinositide lipids with integral and peripheral membrane proteins, leading to modulation of protein structure, function, and cellular distribution. Since the discovery of phosphoinositides in the 1940s, combined molecular biology, biophysical, and structural approaches have made enormous progress in untangling this vast and diverse cellular network of interactions.
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