This study aimed to investigate the effect of traditional Chinese medicine (TCM) intervention on the risk of readmission and laboratory indicators in patients with rheumatoid arthritis hypercoagulable state. In the retrospective cohort design, patients with RA hospitalized between June 2013 and June 2021 at the First Affiliated Hospital of Anhui University of Chinese Medicine were followed up by telephone. Propensity score matching (PSM) was used to balance deviations in baseline information between patients in the hypercoagulable (HC) and non-hypercoagulable (Non-HC) groups, with exposure defined as receiving TCM treatment for ≥ 1 month. Cox proportional hazards model and Kaplan-Meier survival curves were employed to determine the factors influencing the readmission of RA-HC patients. Mantel test and association rule analysis was used to explore the relationship between the included factors and laboratory indicators. A total of 1169 cases were successfully followed up, including 831 RA-HC patients. 1:2 PSM yielded 311 patients in the non-HC group versus 535 patients in the HC group. We observed that the incidence of readmission and surgical treatment was significantly higher in the HC group than in the non-HC group, while the incidence of readmission, surgical treatment, and all-cause mortality was much lower in the exposed group than in the non-exposed group (all P < .05). Based on the Cox proportional risk model, we identified age above 60 years, Sjogren's syndrome, neutrophil count, and neutrophil-lymphocyte ratio (NLR) as risk factors for readmission, with TCM playing a protective role. The Kaplan-Meier survival curves further showed that the risk of readmission in the high-exposure subgroup was markedly lower than that of the low-exposure subgroup. Furthermore, the Mantel test highlights an intrinsic correlation between coagulation markers and other markers such as erythrocyte sedimentation rate (ESR) and hypersensitive c-reactive protein (hs-CRP), which are dramatically influenced by gender, age, etc. In addition, association rule analysis revealed a strong correlation between TCM and non-readmission, as well as improvement in rheumatoid factor, hs-CRP, ESR, platelet count, and NLR in RA-HC patients. As a promising therapeutic strategy, TCM with sufficient intensity and duration interventions can effectively reduce the risk of readmission and relieve laboratory indicators in RA-HC patients.
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http://dx.doi.org/10.1097/MD.0000000000040890 | DOI Listing |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651460 | PMC |
Plant Commun
December 2024
The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, PR China. Electronic address:
World J Surg Oncol
December 2024
Department of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou, Guangdong, 510095, People's Republic of China.
Background: The combination of immunotherapy and chemotherapy has demonstrated an enhancement in progression-free survival (PFS) for individuals with advanced and metastatic triple-negative breast cancer (TNBC) when compared to the use of chemotherapy alone. Nevertheless, the extent to which different subgroups of metastatic TNBC patients experience this benefit remains uncertain.
Objectives: Our objective was to conduct subgroup analyses to more precisely identify the factors influencing these outcomes.
Microbiome
December 2024
MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian, Liaoning, 116024, China.
Background: The overuse of antibiotics has led to lethal multi-antibiotic-resistant microorganisms around the globe, with restricted availability of novel antibiotics. Compared to conventional antibiotics, evolutionarily originated antimicrobial peptides (AMPs) are promising alternatives to address these issues. The gut microbiome of Blattella germanica represents a previously untapped resource of naturally evolving AMPs for developing antimicrobial agents.
View Article and Find Full Text PDFAlzheimers Res Ther
December 2024
Department of Neurology and Institute on Aging and Brain Disorders, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Lujiang Road 17, Hefei, 230001, China.
Background: Recent research has postulated that the activation of cGAS-STING-interferon signalling pathways could be implicated in the pathogenesis of Alzheimer's disease (AD). However, the precise types of interferons and related cytokines, both from the brain and periphery, responsible for cognitive impairment in patients with AD remain unclear.
Methods: A total of 131 participants (78 [59.
Clin Epigenetics
December 2024
Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, 310022, Zhejiang, China.
Background: Pancreatic adenocarcinoma (PDAC) exhibits a complex microenvironment with diverse cell populations influencing patient prognosis. Single-cell RNA sequencing (scRNA-seq) was used to identify prognosis-related cell types, and DNA methylation (DNAm)-based models were developed to predict outcomes based on their cellular characteristics.
Methods: We integrated scRNA-seq, bulk data, and clinical information to identify key cell populations associated with prognosis.
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