Cognitive impairment represents a core and prodromal clinical feature of cerebral amyloid angiopathy (CAA). We sought to assess specific cognitive domains which are mainly affected among patients with CAA and to investigate probable associations with neuroimaging markers and Cerebrospinal Fluid (CSF) biomarkers. Thirty-five patients fulfilling the Boston Criteria v1.5 or v2.0 for the diagnosis of probable/possible CAA were enrolled in this prospective cohort study. Brain Magnetic Resonance Imaging and CSF biomarker data were collected. Every eligible participant underwent a comprehensive neurocognitive assessment. Spearman's rank correlation tests were used to identify possible relationships between the Addenbrooke's Cognitive Examination-Revised (ACE-R) sub-scores and other neurocognitive test scores and the CSF biomarker and neuroimaging parameters among CAA patients. Moreover, linear regression analyses were used to investigate the effects of CSF biomarkers on the ACE-R total score and Mini-Mental State Examination (MMSE) score, based on the outcomes of univariate analyses. Cognitive impairment was detected in 80% of patients, and 60% had a coexistent Alzheimer's disease (AD) pathology based on CSF biomarker profiles. Notable correlations were identified between increased levels of total tau (t-tau) and phosphorylated tau (p-tau) and diminished performance in terms of overall cognitive function, especially memory. In contrast, neuroimaging indicators, including lobar cerebral microbleeds and superficial siderosis, had no significant associations with cognitive scores. Among the CAA patients, those without AD had superior neurocognitive test performance, with significant differences observed in their ACE-R total scores and memory sub-scores. The significance of tauopathy in cognitive impairment associated with CAA may be greater than previously imagined, underscoring the necessity for additional exploration of the non-hemorrhagic facets of the disease and new neuroimaging markers.

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm13237427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11642001PMC

Publication Analysis

Top Keywords

cognitive impairment
16
csf biomarker
12
cognitive
8
cerebral amyloid
8
amyloid angiopathy
8
prospective cohort
8
cohort study
8
neuroimaging markers
8
csf biomarkers
8
neurocognitive test
8

Similar Publications

Objective: Technology can be combined with psychological interventions to support older adults with memory concerns. Using a bi-phasic design, cognitive rehabilitation (CR) was integrated with off-the-shelf technology and delivered to two people with cognitive impairment, and one care partner.

Method: Pre- and post-intervention assessments were completed for all participants.

View Article and Find Full Text PDF

Brain derived β-interferon is a potential player in Alzheimer's disease pathogenesis and cognitive impairment.

Alzheimers Res Ther

December 2024

Department of Neurology and Institute on Aging and Brain Disorders, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Lujiang Road 17, Hefei, 230001, China.

Background: Recent research has postulated that the activation of cGAS-STING-interferon signalling pathways could be implicated in the pathogenesis of Alzheimer's disease (AD). However, the precise types of interferons and related cytokines, both from the brain and periphery, responsible for cognitive impairment in patients with AD remain unclear.

Methods: A total of 131 participants (78 [59.

View Article and Find Full Text PDF

Background: Postoperative delirium (POD) is a cognitive decline and attention deficit that can occur in patients after cardiac surgery. Despite extensive research identifying the risk factors, POD often remains undiagnosed and untreated in medical settings. Therefore, this systematic literature review (SLR) aimed to summarize the available studies on early POD identification in patients following cardiovascular surgery.

View Article and Find Full Text PDF

The association between malnutrition, depression and cognitive decline in free-living elderly people in Cyprus: a cross-sectional study.

BMC Public Health

December 2024

Department of Life Sciences, School of Sciences, European University Cyprus, 6 Diogenes Str. Engomi, 2404, P.O. Box: 22006, Nicosia, 1516, Cyprus.

Background: Malnutrition, depression, and cognitive decline are significant concerns among the elderly population, yet the relationship between these factors remains underexplored, particularly in Cyprus. This study aimed to assess the prevalence of malnutrition, depression, and cognitive decline in free-living elderly people in Cyprus and to explore the associations between these conditions and various anthropometric, social, and dietary factors.

Methods: A cross-sectional study was conducted with 248 participants aged ≥ 60 years, using convenience sampling.

View Article and Find Full Text PDF

Background: The number of people reaching old age is rising, bringing an increase in age-related diseases like cardiovascular conditions and cognitive dysfunction. Cognitive impairment (CI) impacts various brain functions, affecting daily activities and quality of life. Metabolic syndrome (MetS), a cluster of cardiovascular risk factors, has been implicated in CI.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!