: Sodium-glucose co-transporter 2 (SGLT-2) inhibitors, initially designed for type 2 diabetes, promote glucose excretion and lower blood glucose. Newer analogs like empagliflozin and dapagliflozin improve cardiovascular outcomes through mechanisms other than glycemic control, including blood pressure reduction and anti-inflammatory effects. Given the high cardiovascular risk present in diabetes, our study aims to emphasize the cardioprotective benefits of SGLT-2 inhibitors as a preventive therapy for heart failure (HF) in high-risk T2DM patients. : Using data from 2542 patients identified by the ICD-10 E11 code from 2016 to 2020, this longitudinal study excluded those with E10 codes or those undergoing insulin treatment to focus on non-insulin-dependent T2DM. a multiple logistic regression model assessed HF incidence while adjusting for demographics and HbA1c. : SGLT-2 inhibitor use significantly lowered the odds of heart failure events (OR = 0.55, 95% CI: 0.31-0.99, = 0.046), with a significant difference by gender (OR = 0.45, 95% CI: 0.28-0.71, = 0.001) and eGFR (OR = 0.98, 95% CI: 0.97-0.99, = 0.004). : The real-world data highlight SGLT-2 inhibitors as promising for HF prevention and broader cardiometabolic health in T2DM, with potential value in managing complex comorbid profiles.

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm13237093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11642396PMC

Publication Analysis

Top Keywords

sglt-2 inhibitors
16
heart failure
12
type diabetes
8
sglt-2
5
protective influence
4
influence sglt-2
4
inhibitors
4
inhibitors heart
4
failure type
4
diabetes mellitus
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!