The issue of slope stability in earthquakes has become increasingly prominent with the construction of many infrastructure projects such as highways, bridges, and tunnels. To explore the dynamic response characteristics of bedding rock slopes in an earthquake, the three-dimensional dynamic finite-difference method (TDD-FDM) in this study is used to establish simplified rock slope models, taking a bedding rock slope with alternatively distributed soft and hard rock layers in Yunnan, China as a prototype. The dynamic response mechanism of layered rock slopes containing different thicknesses, locations, and quantities of soft rock layers was studied under different excitation directions of seismic waves. The main findings are that the propagation of seismic waves at different rock layer structures has directionality, which causes the strongest seismic response to be all located in the upper or middle parts of the slope; the influence of rock structures on seismic response in layered rock slopes is in the order of thickness > quantity > location; the acceleration amplification effect of a slope under multi-directional seismic wave excitation exhibits the phenomena of differential amplification and coupling amplification; and the acceleration amplification factors of a slope with increasing peak ground acceleration from 0.05 g to 0.20 g show two trends: increasing-decreasing and continuous increasing. The findings of this study can be a reference for studying the dynamic response of rock slopes in strong earthquakes.
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http://dx.doi.org/10.3390/ma17235939 | DOI Listing |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11643936 | PMC |
J Virol
December 2024
College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, Beijing, China.
Unlabelled: Quorum sensing (QS) can regulate diverse critical phenotypic responses in (), enabling bacterial adaptation to external environmental fluctuations and optimizing population advantages. While there is emerging evidence of QS's involvement in influencing phage infections, our current understanding remains limited, necessitating further investigation. In this study, we isolated and characterized a novel phage designated as BUCT640 that infected PAO1.
View Article and Find Full Text PDFJ Chem Phys
January 2025
Dipartimento di Fisica, Università degli Studi di Napoli Federico II, and INFN Napoli, Complesso Universitario di Monte Sant'Angelo, 80126 Naples, Italy.
In the last years, it has been proved that some viruses are able to re-structure chromatin organization and alter the epigenomic landscape of the host genome. In addition, they are able to affect the physical mechanisms shaping chromatin 3D structure, with a consequent impact on gene activity. Here, we investigate with polymer physics genome re-organization of the host genome upon SARS-CoV-2 viral infection and how it can impact structural variability within the population of single-cell chromatin configurations.
View Article and Find Full Text PDFChem Rec
January 2025
Lab of Functional and Biomedical Nanomaterials, College of Materials Science and Engineering, Qingdao University of Science and Technology (QUST), Qingdao, 266042, P. R. China.
Triple-negative breast cancer (TNBC) represents a highly aggressive and prognostically unfavorable subtype of breast cancer, characterized by the absence of common hormone receptors, which renders conventional therapies largely ineffective. This review comprehensively examines the molecular and clinical characteristics of TNBC, underscoring the substantial challenges inherent in its treatment and the innovative potential of targeted nanoprobes in advancing both diagnostic and therapeutic paradigms. Through the modification of targeting molecules, nanoprobes can deliver therapeutic agents highly specific to TNBC cells, thus significantly improving the sensitivity of diagnostic modalities and the efficacy of therapeutic interventions.
View Article and Find Full Text PDFMicrosc Res Tech
January 2025
Department of Computer Science, Cihan University, Sulaimaniyah, Kurdistan Region, Iraq.
Waveguide evanescent field fluorescence microscopy (WEFF) is an evanescent-based microscopy that utilizes a confined thin film of light, around 100 nm, to image the plasma membrane of cells attached to a waveguide. Low photobleaching and low background besides its high axial resolution allows time-lapse imaging to investigate changes in cell morphology in the presence or absence of chemical agents. Both large field of view (FOV) and uniform illumination are very important while imaging cell-substrate contacts with an evanescent field.
View Article and Find Full Text PDFPathog Glob Health
January 2025
Centro Estadual de Vigilância em Saúde, Secretaria de Saúde do Estado do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, do Sul, Brazil.
Mpox is a zoonotic viral disease caused by the (MPXV). Human cases have been mainly restricted to the African continent until the worldwide multi-country outbreak unfolded in 2022. We reconstructed epidemiological links of 53 MPXV infections using genomic epidemiology in Rio Grande do Sul State, southern Brazil, during 2022 and 2023.
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