AI Article Synopsis
- * It involved 50 participants, comparing 26 OA patients to 24 non-OA controls, assessing pain intensity using visual analogue scales (VAS) and cognitive function through the Cognitive Abilities Screening Instrument (CASI).
- * Results revealed that OA patients generally performed worse on cognitive tests, with pain severity correlating negatively with cognitive scores, while certain brain biomarkers were found to be positively correlated with pain, indicating that chronic pain and higher Alzheimer’s biomarkers may influence cognitive decline in OA patients.
Article Abstract
Considerable studies have demonstrated that osteoarthritis (OA) is a risk factor for dementia. The precise mechanisms underlying the association between OA and increased risk for cognitive dysfunction, however, remain unclear. This study aimed at exploring the associations between pro-inflammatory cytokines/chemokines, biomarkers of Alzheimer's disease (AD), pain intensity, and cognitive decline in knee joint OA patients. A total of 50 patients (26 in OA group and 24 in non-OA control group) were enrolled in this prospective, observational study. The visual analogue scale (VAS) score for pain intensity and Cognitive Abilities Screening Instrument (CASI) score for cognitive functions were examined in both groups. The plasma and cerebrospinal fluid (CSF) levels of pro-inflammatory molecules (IL-1β, IL-6, TNF-α, fractalkine, BDNF, MCP-1, and TGF-β), as well as biomarkers of AD (Aβ, Aβ, total-tau, and phospho-tau), were measured by multiplex immunoassay. Correlations among plasma or CSF biomarkers and questionnaire scores were assessed using Pearson's correlation coefficient and simple linear regressions. There were more patients in the OA group whose CASI cutoff percentiles were
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http://dx.doi.org/10.3390/ijms252312575 DOI Listing http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11641244 PMC Publication Analysis
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