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Chronic skin conditions, such as atopic dermatitis, are characterized by a weakened skin barrier and persistent inflammation. Traditional treatments can frequently cause substantial side effects, emphasizing the need for safer alternatives. This study investigated the anti-inflammatory properties of goat meat extract and its effects on improving skin function. We conducted wound healing assays using HaCaT cells and analyzed the expression of key skin barrier-related genes. Additionally, the anti-inflammatory effects of goat meat extract were assessed in HaCaT cells stimulated with TNFα and IFNγ, as well as in LPS-treated RAW264.7 cells. Mechanistic studies focused on the activation of mitogen-activated protein kinase (MAPK) pathways. The results showed that goat meat extract significantly promoted wound closure in HaCaT cells and upregulated the expression of filaggrin, loricrin, and involucrin. The extract also reduced the production of pro-inflammatory cytokines and chemokines in both HaCaT and RAW264.7 cells. Furthermore, it inhibited the activation of the JNK, p38, and ERK pathways in TNFα/IFNγ-stimulated HaCaT cells. These findings suggest that goat meat extract improves skin barrier function and exhibits anti-inflammatory effects, indicating its potential as a therapeutic agent for chronic skin. Further research is required to investigate the in vivo effects of goat meat extract and validate its therapeutic potential.
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http://dx.doi.org/10.3390/foods13233934 | DOI Listing |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11641237 | PMC |
Vet Med Int
December 2024
Department of Animal Production Technology, College of Technology, The University of Bamenda, P.O. Box 39, Bambili, Bamenda, Cameroon.
Sheep and goat influence the socioeconomic sustainability of rural communities in tropical countries, but parasitic diseases and in particular are responsible for their low productivity. The occurrence of in most affected regions of the world has been associated to the presence of stray dogs in the grazing area, which play vital roles in the life cycle of the parasite and poor disposal of contaminated and seized offal, organs, and carcasses. The aim of this paper is to systematically review the epidemiology of infection in sheep and goats in the tropics between 2010 and 2022 through the analysis of published qualitative and quantitative data on prevalence, risk factors, organ distribution, and interventions.
View Article and Find Full Text PDFPLoS Negl Trop Dis
December 2024
Department of Veterinary Anatomy and Pathology, College of Veterinary Medicine and Biomedical Sciences, Sokoine University of Agriculture, Morogoro, Tanzania.
Background: Brucellosis poses serious public health implications and substantial economic losses in pastoral rural settings in South Sudan. In humans, brucellosis is almost always originating from animals. Current literature provides scant data regarding the seroprevalence of brucellosis in South Sudan.
View Article and Find Full Text PDFHeliyon
December 2024
Department of Animal Resources Science, Kongju National University, Yesan, 32439, Republic of Korea.
This study investigated the tenderization and quality characteristics of Korean black goat biceps femoris treated with ginger powder extracts (0 %, 3 %, 5 %, and 7 %). The proximate composition, pH, color, shear force, water-holding capacity, sarcomere length, fiber cross-sectional area, and sensory properties were determined and analyzed according to the concentration of the ginger powder extract. The shear force decreased significantly with increasing concentrations of ginger powder extract ( < 0.
View Article and Find Full Text PDFSci Data
December 2024
College of Animal Science, Xichang University, Xichang, 615000, China.
Lamb meat is highly valued across various cultures and regions due to its unique flavor and nutritional benefits. As the primary component of edible meat, skeletal muscle holds significant economic value and research importance. However, previous studies have largely focused on a limited array of muscle groups, overlooking the differences between various types.
View Article and Find Full Text PDFFoods
December 2024
Animal Products Utilization Division, National Institute of Animal Science, RDA, Wanju 55365, Republic of Korea.
Chronic skin conditions, such as atopic dermatitis, are characterized by a weakened skin barrier and persistent inflammation. Traditional treatments can frequently cause substantial side effects, emphasizing the need for safer alternatives. This study investigated the anti-inflammatory properties of goat meat extract and its effects on improving skin function.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!