Background/objectives: Bladder cancer is a type of cancer that begins in the cells lining the inner surface of the bladder. Although it usually begins in the bladder, it can spread to surrounding tissues, lymph nodes, and other organs in later stages. Early detection of bladder cancer is, therefore, of great importance.
Methods: Therefore, this study developed two systems based on classification and Content-Based Image Retrieval (CBIR). The primary purpose of CBIR systems is to compare the visual similarities of a user-provided image with the images in the database and return the most similar ones. CBIR systems offer an effective search and retrieval mechanism by directly using the content of the image data.
Results: In the proposed CBIR system, five different CNNs, two different textural-based feature extraction methods, and seven different similarity measurement metrics were tested for feature selection and similarity measurement. Successful feature extraction methods and similarity measurement metrics formed the infrastructure of the developed system. Densenet201 was preferred for feature extraction in the developed system. The cosine metric was used in the proposed CBIR system as a similarity measurement metric, the most successful among seven different metrics.
Conclusions: As a result, it was seen that the proposed CBIR model showed the highest success using the Densenet201 model for feature extraction and the Cosine similarity measurement method.
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http://dx.doi.org/10.3390/diagnostics14232637 | DOI Listing |
NMR Biomed
February 2025
Department of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.
Cellular metabolism is inextricably linked to transmembrane levels of proton (H), sodium (Na), and potassium (K) ions. Although reduced sodium-potassium pump (Na-K ATPase) activity in tumors directly disturbs transmembrane Na and K levels, this dysfunction is a result of upregulated aerobic glycolysis generating excessive cytosolic H (and lactate) which are extruded to acidify the interstitial space. These oncogene-directed metabolic changes, affecting intracellular Na and H, can be further exacerbated by upregulation of ion exchangers/transporters.
View Article and Find Full Text PDFActa Paediatr
January 2025
Centre for Adolescent Health, Murdoch Children's Research Institute and Royal Children's Hospital, Parkville, Victoria, Australia.
Aim: Most studies of prepubertal weight and puberty have not used continuous or long follow-up periods. We explored the effect that birth weight and growth trajectories from 0-9 years of age had on starting puberty.
Methods: Data were obtained from 1510 children in Tianjin, China, who were born in 2013 and selected by cluster random sampling.
Postgrad Med J
January 2025
Proof of Concept Center, Eastern Hepatobiliary Surgery Hospital, Third Affiliated Hospital, Second Military Medical University, Naval Medical University, No. 255, Yangpu District, Shanghai, 200433, China.
Objectives: The objective was to investigate the role of double extraction in reducing data errors in evidence synthesis for pharmaceutical and non-pharmaceutical interventions.
Design: Crossover randomized controlled trial (RCT).
Setting: University and hospital with teaching programs in evidence-based medicine.
J Sci Food Agric
January 2025
Department of Food Technology, Fulda University of Applied Sciences, Fulda, Germany.
Background: Understanding the size and surface charge (ζ-potential) of particles in the mixed micellar fraction produced by in vitro digestion is crucial to understand their cellular absorption and transport. The inconsistent presentation of micellar size data, often limited to average particle diameter, makes comparison of studies difficult. The present study aimed to assess different size data representations (mean particle diameter, relative intensity- or volume-weighted size distribution) to better understand physiological mixed micelle characteristics and to provide recommendations for size reporting and sample handling.
View Article and Find Full Text PDFFront Microbiol
December 2024
Department of Earth Sciences, University of Southern California, Los Angeles, CA, United States.
Microbial activity in the deep continental subsurface is difficult to measure due to low cell densities, low energy fluxes, cryptic elemental cycles and enigmatic metabolisms. Nonetheless, direct access to rare sample sites and sensitive laboratory measurements can be used to better understand the variables that govern microbial life underground. In this study, we sampled fluids from six boreholes at depths ranging from 244 m to 1,478 m below ground at the Sanford Underground Research Facility (SURF), a former goldmine in South Dakota, United States.
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