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Uncovering a cryptic Streptococcus suis endemic post-outbreak: Evidence of host switching to humans.
Sci Total Environ
January 2025
Department of Critical Care Medicine, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China. Electronic address:
Streptococcus suis (S. suis) is a neglected and emerging pathogen that leads to severe economic losses in swine industry. Despite its epidemic potential, the zoonotic threat posed by S.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Université de Montpellier, Montpellier, France.
Background: Protein metabolism and turnover can be monitored using tracer methods, notably stable isotope labeling kinetics (SILK) based on 13C-leucine incorporation. This approach has been used in Alzheimer's disease, specifically analyzing the turnover in cerebrospinal fluid of biomarkers of interest, including amyloid peptides, leading to major pathophysiological insights (Nature medicine 12:856-861). This was achieved using immunoprecipitation mass spectrometry, which enables to track a small number of targets present in low concentration.
View Article and Find Full Text PDFThe hidden role of heterotrophic bacteria in early carbonate diagenesis.
Sci Rep
January 2025
Ali I. Al-Naimi Petroleum Engineering Research Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
Microbial impacts on early carbonate diagenesis, particularly the formation of Mg-carbonates at low temperatures, have long eluded scientists. Our breakthrough laboratory experiments with two species of halophilic aerobic bacteria and marine carbonate grains reveal that these bacteria created a distinctive protodolomite (disordered dolomite) rim around the grains. Scanning Electron Microscopy (SEM) and X-ray Diffraction (XRD) confirmed the protodolomite formation, while solid-state nuclear magnetic resonance (NMR) revealed bacterial interactions with carboxylated organic matter, such as extracellular polymeric substances (EPS).
View Article and Find Full Text PDFHidden features: CD36/SR-B2, a master regulator of macrophage phenotype/function through metabolism.
Front Immunol
January 2025
Mike Petryk School of Dentistry, Faculty of Medicine and Dentistry, College of Health Sciences, University of Alberta, Edmonton, AB, Canada.
Once thought to be in a terminally differentiated state, macrophages are now understood to be highly pliable, attuned and receptive to environmental cues that control and align responses. In development of purpose, the centrality of metabolic pathways has emerged. Thus, macrophage inflammatory or reparative phenotypes are tightly linked to catabolic and anabolic metabolism, with further fine tuning of specific gene expression patterns in specific settings.
View Article and Find Full Text PDFHidden route of protein damage through oxygen-confined photooxidation.
Nat Commun
December 2024
Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, 44919, Republic of Korea.
Oxidative modifications can disrupt protein folds and functions, and are strongly associated with human aging and diseases. Conventional oxidation pathways typically involve the free diffusion of reactive oxygen species (ROS), which primarily attack the protein surface. Yet, it remains unclear whether and how internal protein folds capable of trapping oxygen (O) contribute to oxidative damage.
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