Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Dye biodegradation products may cause genotoxicity, raising concerns about the safety of bioremediated water. The underlying biotransformation mechanism and related genotoxicity during anthraquinone degradation remain unclear. In this study, we employed Pseudomonas aeruginosa WYT (PaWYT) to investigate the biotransformation of Vat Blue 4 (VB4), a dye with a typical anthraquinone structure and low bioavailability. The genotoxicity of the resulting degradation products was also assessed. Novel mechanisms for VB4 biotransformation were identified, including piperazine cleavage, chromophore loss, and the formation of smaller molecular products. A real-time genotoxicity assay showed that VB4 induced oxidative and general stresses to microorganisms, while the total genotoxicity across five stress categories (oxidative, protein, membrane, DNA, and general stresses) gradually decreased as the dye degradation progressed. Overall, capturing and understanding the toxicity dynamics during VB4 bioremediation supports the reliability of this biodegradation method and its potential for treating VB4-contaminated wastewater.
Download full-text PDF |
Source |
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http://dx.doi.org/10.1016/j.biortech.2024.131978 | DOI Listing |
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