Personalized melanoma grading system: a presentation of a patient with four melanomas detected over two decades with evolving whole-body imaging and artificial intelligence systems.

Melanoma is a life-threatening tumor that significantly impacts individuals' health and society worldwide. Therefore, its diagnostic tools must be revolutionized, representing the most remarkable human efforts toward successful management. This retrospective study includes the multidimensional analysis of five melanomas in a man in our clinic including whole-body photography, dermatoscopy, artificial intelligence system, genetic test, and the final histopathological conclusion. The correlation between findings in each diagnostic step is discussed. The value of the melanoma grading system will be the application in high-risk lesions to make the right management decision.