Multisubstituted piperidines are prevalent units in pharmaceuticals. Herein, a photodriven anti-Markovnikov hydroaminative cyclization of a ()/()-isomeric mixture of trisubstituted alkenes using the lactate-derived -symmetric arylthiol catalyst was developed for the synthesis of -2,3-disubstituted piperidines and azepane in high diastereoselectivity and good yields. The origin of diastereoselectivity and the observed different hydroamination rate of alkene with different configurations were elucidated by the experimental and computational investigation.
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Intramolecular Anti-Markovnikov Alkene Hydroaminative Cyclization to -2,3-Disubstituted Piperidines.
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Shanghai Key Laboratory of Green Chemistry and Chemical Processes, State Key Laboratory of Petroleum Molecular & Process Engineering, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.
Multisubstituted piperidines are prevalent units in pharmaceuticals. Herein, a photodriven anti-Markovnikov hydroaminative cyclization of a ()/()-isomeric mixture of trisubstituted alkenes using the lactate-derived -symmetric arylthiol catalyst was developed for the synthesis of -2,3-disubstituted piperidines and azepane in high diastereoselectivity and good yields. The origin of diastereoselectivity and the observed different hydroamination rate of alkene with different configurations were elucidated by the experimental and computational investigation.
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