AI Article Synopsis
- Conventional radiation therapy helps cells to trigger immunogenic cell death, making it a potential method for cancer treatment.
- Recent studies indicate that targeted radionuclide therapy could enhance the immune response and may help address challenges with immune checkpoint inhibitors in cancer therapy.
- Research shows that irradiated cells can release extracellular vesicles that activate the immune system, adding to the body's ability to fight tumors.
Article Abstract
Conventional radiation therapy can restore the ability of cells to undergo immunogenic cell death. Recent preclinical studies suggest that targeted radionuclide therapy, which delivers radiation to tumors at a continuous low dose rate, also stimulates the immune system and offers a promising approach for overcoming resistance to immune checkpoint inhibitors. In this context, we examined the growing body of preclinical and clinical findings showing that the immune system can be activated by the release of extracellular vesicles from irradiated cells, contributing to the antitumor immunity.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11647936 | PMC |
| http://dx.doi.org/10.1093/jrr/rrae084 | DOI Listing |
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