AI Article Synopsis
- This study focuses on developing nanoparticles (PCD) that can change size in response to pH levels, enhancing their ability to target tumors effectively.
- The researchers used a boronate ester to link β-cyclodextrin polymers, allowing the nanoparticles to release the anti-cancer drug doxorubicin in acidic environments found in tumors.
- Results showed that PCD nanoparticles were stable in the bloodstream, allowing for prolonged circulation, and once they reached tumors, they broke down into smaller particles that penetrated tumor tissues more effectively than a control non-responsive nanoparticle (UCD).
Article Abstract
Nanomedicines whose size can be varied on demand may synchronously achieve excellent tumor accumulation and penetration. In this study, by taking advantage of the pH sensitivity of a boronate ester, we synthesized acid-triggered size-reducing polymer nanoparticles (named PCD) by cross-linking β-cyclodextrin-cored multiarm polymers through the boronate ester. In PCD, the antitumor agent doxorubicin was loaded the pH-sensitive hydrazone linkage. The and properties of PCD were investigated using a non-responsive nanoparticle (named UCD) as a reference. In the neutral condition of the bloodstream, PCD was stable and exhibited a suitable size for long circulation time. Upon entering tumors, PCD decomposed into stable and smaller multiarm polymers, which could deeply penetrate tumors. The high tumor accumulation and penetration of PCD offered significantly better anti-tumor efficacy than UCD.
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| http://dx.doi.org/10.1039/d4bm01121j | DOI Listing |
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