Photothermal optical coherence microscopy (PT-OCM) combines the high-resolution, label-free morphological imaging of OCM with the ability to discriminate tissue composition through phase-sensitive photothermal imaging. In this study, we perform 2D imaging of human carotid endarterectomies to spectrally determine lipid distribution, with verification via histologically stained samples. The structural information from OCM is combined with the spectral information gained from measuring the resulting sample surface displacement from thermoelastic expansion, following light irradiation. PT-OCM is thus demonstrated as a potential tool in the investigation of atherosclerotic plaque lipids, contributing towards the understanding of plaque instability.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11640572PMC
http://dx.doi.org/10.1364/BOE.534800DOI Listing

Publication Analysis

Top Keywords

photothermal optical
8
optical coherence
8
coherence microscopy
8
human carotid
8
microscopy studying
4
studying lipid
4
lipid architecture
4
architecture human
4
carotid arteries
4
arteries photothermal
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!