Introduction Rectal cancer forms a significant proportion of newly diagnosed colorectal cancer. Treatment of rectal cancer is multi-modal, but surgery remains the cornerstone of treatment of rectal cancer and has undergone significant changes in the last three decades. The advent of minimally invasive techniques has revolutionised the landscape of surgery of the rectum. There is now a growing push to centralise rectal cancer surgery to tertiary centres only. We present the results of rectal cancer surgery from our district hospital. Methods This is a single-centre retrospective review of patients undergoing rectal cancer surgery from January 2018 to December 2019 at Northern Lincolnshire and Goole Trust. Results A total of 104 patients were included, with a mean age of 69.13 years (median 70, range 45-98 years). Of the patients, 65 (62.5%) patients were male and 39 (37.5%) patients were female. Neoadjuvant therapy was given to 34% of patients, while 66% of patients underwent surgery first. Anterior resection was performed in 64% of patients, abdomino-perineal resection was performed in 24% of patients, and Hartmann's type operations were performed in 9% of patients. Median length of stay was 9 days (range 2-78 days). Morbidity was 24%, and five patients had anastomotic leaks, of whom three had radiological drain insertion and two required re-operation. Mortality was 2.,8% and re-operations were performed in 2% of patients. Conclusion Rectal cancer surgery can be safely undertaken in district hospitals with adequately trained surgeons using a multi-disciplinary approach.
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http://dx.doi.org/10.7759/cureus.75664 | DOI Listing |
Front Oncol
December 2024
Department of General Surgery, General Hospital of Northern Theater Command, Shenyang, China.
It is well established that host immunity plays a critical role in defending against colorectal cancer (CRC) progression. Connective tissue disease (CTD) encompasses a group of heterogeneous, immune-mediated disorders that present with diverse and often non-specific initial symptoms. Raynaud's phenomenon is a common feature, complicating early diagnosis.
View Article and Find Full Text PDFPharm Dev Technol
December 2024
Nanomedicine Research Group, Department of Pharmacy, Quaid-i-Azam University, Islamabad 45320, Pakistan.
This study aims to develop a thermoresponsive biomaterial system of irinotecan (IRT) and curcumin (CUR) nano-transferosomal gel (IRT-CUR-NTG) for targeting colorectal cancer (CRC). The IRT-CUR-NTs were statistically optimized and loaded into poloxamer-based thermosensitive gel. Transmission electron microscopy (TEM), Differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy (FTIR) of the IRT-CUR-NTs were performed, whereas pH, gelation time, gelation temperature, gel and mucoadhesive strength of the IRT-CUR-NTG were investigated.
View Article and Find Full Text PDFBMC Cancer
December 2024
Department of Colorectal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Background: Accurate prediction of pathological complete response (pCR) and disease-free survival (DFS) in locally advanced rectal cancer (LARC) patients undergoing neoadjuvant chemoradiotherapy (NCRT) is essential for formulating effective treatment plans. This study aimed to construct and validate the machine learning (ML) models to predict pCR and DFS using pathomics.
Method: A retrospective analysis was conducted on 294 patients who received NCRT from two independent institutions.
JMIR Public Health Surveill
December 2024
Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore, SG.
Background: Colorectal cancer (CRC) incidence and mortality in those aged 50 years and above have decreased over the last 2 decades. However, there is a rising incidence in CRC among individuals under 50 years of age, termed early-onset colorectal cancer (EOCRC). EOCRC patients are more advanced stage at diagnosis and may suffer more psychosocial, emotional and financial distress.
View Article and Find Full Text PDFUpdates Surg
December 2024
Department of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA.
Anal Melanoma (AM) is a rare and aggressive disease lacking standardized treatment protocols. Despite advancements in medical oncology, the 5-year overall survival (OS) remains at 20%. Local surgery (LS) has gained popularity over radical surgery (RS) due to its comparable OS when negative margins are achieved.
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