Non-structural protein 2 (nsP2), which plays an essential role in replication of CHIKV, contains a protease, helicase, and methyltransferase-like domain. We executed a simple a screen using malachite green to detect compounds that decreased ATP hydrolysis and tested a library of diverse compounds to find inhibitors of CHIKV nsP2 helicase.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11642811 | PMC |
| http://dx.doi.org/10.1101/2024.12.02.625520 | DOI Listing |
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