Primary oesophageal lymphoma is an exceptionally rare cancer originating in the esophagus, distinct from more common oesophageal malignancies. Dawson's criteria has been the mainstay for diagnosis for such entities. However, recognizing primary oesophageal lymphoma is particularly challenging due to its rarity, diverse clinical presentations, and non-specific radiological and endoscopic features. These factors often lead to diagnostic delays, complicating timely treatment and resulting in poor patient outcomes. We hereby present a challenging case and literature review about this rare malignancy. A 78-year-old male was referred to Gastroenterology for evaluation of dysphagia. Initial esophagogastroduodenoscopy (OGD) revealed an oesophageal ulcer with features consistent with oesophageal candidiasis. A follow-up OGD identified an oesophageal stricture. Histopathology and immunohistochemistry of biopsy samples confirmed a diagnosis of diffuse large B-cell lymphoma (DLBCL). A staging CT was completed, and an oesophageal mass was shown extending into the mediastinum. The patient re-presented with worsening dysphagia, renal dysfunction, and hypercalcemia. Although lymphoma was confirmed, to ensure an appropriate regimen is commenced, a repeat OGD was recommended by the Hematology team. The patient's rapid deterioration necessitated pre-phase steroid treatment and management of tumor lysis syndrome. Before R-CHOP chemotherapy could begin, the patient deteriorated further. Following a multidisciplinary team (MDT) meeting and discussions with the patient and family, it was decided to manage the symptoms with palliative intent. This case highlights the diagnostic challenges posed by primary oesophageal lymphoma, emphasizing the importance of considering this rare malignancy in the differential diagnosis of oesophageal strictures, particularly in elderly patients. Aggressive disease progression complicates managing DLBCL in older patients. Moreover, this patient population has other co-morbidities that would preclude treatment options at the outset. Further studies are needed to establish optimal diagnostic and therapeutic strategies for this rare condition.
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http://dx.doi.org/10.7759/cureus.73751 | DOI Listing |
Eur J Nutr
December 2024
Department of Thoracic Surgery, Med+X Center for Informatics, West China Hospital, Sichuan University, Chengdu, China.
Objective: Previous studies have indicated a potential correlation between cheese intake and risk of various diseases. However, establishing a causal relationship is challenging. To address this, we employed Mendelian randomization (MR) to simulate randomized trial groups and to investigate whether there is a causal link between cheese intake and the risk of gastroesophageal reflux disease (GERD) and Barrett's esophagus.
View Article and Find Full Text PDFJACC Clin Electrophysiol
November 2024
Arrhythmia and Robotic EP Unit, Cardiology Department, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain. Electronic address:
Background: The optimal radiofrequency application (RFa) parameters for safe and durable pulmonary vein isolation (PVI) are debated. High-power short-duration (HPSD) has been used as an alternative to conventional power delivery (CPD).
Objectives: This study sought to compare HPSD 70 W/9-10 s (HPSD-70) with CPD 25-40 W in patients undergoing PVI.
Case Rep Gastrointest Med
December 2024
Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Esophageal embryonal rhabdomyosarcoma (ERMS), a rare pediatric cancer, mimicked achalasia in a case involving dysphagia and vomiting. Diagnosis and chemotherapy necessitate careful monitoring due to potential complications. A 12-year-old girl with no prior medical history presented with progressive dysphagia and vomiting.
View Article and Find Full Text PDFClin Exp Hepatol
September 2024
Division of Gastroenterology and Hepatology, University of Pennsylvania Perelman School of Medicine, USA.
Aim Of The Study: Sarcoidosis is characterized by noncaseating granulomas that can affect multiple organs. Due to the lack of prospective studies regarding treatment of hepatic sarcoidosis with ursodeoxycholic acid (UDCA), we set out to evaluate its effects in a single-center, open-label, prospective, pre-post study.
Material And Methods: A total of 10 patients were screened from August 2018 to July 2020; seven met the criteria and were enrolled.
Front Immunol
December 2024
Department of Thoracic Surgery, Jining No. 1 People's Hospital, Jining, Shandong, China.
Background: The study was conducted in order to investigate whether neoadjuvant immunotherapy combined with chemotherapy can bring survival benefits to patients with locally advanced resectable esophageal squamous cell carcinoma (ESCC) in the real world.
Methods: We retrospectively analysed patients with locally advanced resectable ESCC who underwent surgery at the Jining First People's Hospital from April 2020 to April 2022. Based on their medical history, the enrolled patients were divided into a neoadjuvant immunochemotherapy plus surgery group (nICT group) and a surgery-only group (S group).
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