Multispectral photoacoustic tomography (PAT) is an imaging modality that utilizes the photoacoustic effect to achieve non-invasive and high-contrast imaging of internal tissues but also molecular functional information derived from multi-spectral measurements. However, the hardware cost and computational demand of a multispectral PAT system consisting of up to thousands of detectors are huge. To address this challenge, we propose an ultra-sparse spiral sampling strategy for multispectral PAT, which we named U3S-PAT. Our strategy employs a sparse ring-shaped transducer that, when switching excitation wavelengths, simultaneously rotates and translates. This creates a spiral scanning pattern with multispectral angle-interlaced sampling. To solve the highly ill-conditioned image reconstruction problem, we propose a self-supervised learning method that is able to introduce structural information shared during spiral scanning. We simulate the proposed U3S-PAT method on a commercial PAT system and conduct animal experiments to verify its performance. The results show that even with a sparse sampling rate as low as 1/30, our U3S-PAT strategy achieves similar reconstruction and spectral unmixing accuracy as non-spiral dense sampling. Given its ability to dramatically reduce the time required for three-dimensional multispectral scanning, our U3S-PAT strategy has the potential to perform volumetric molecular imaging of dynamic biological activities.
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http://dx.doi.org/10.1016/j.pacs.2024.100641 | DOI Listing |
Insights Imaging
December 2024
Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, Germany.
Objectives: Recently, epicardial adipose tissue (EAT) assessed by CT was identified as an independent mortality predictor in patients with various cardiac diseases. Our goal was to develop a deep learning pipeline for robust automatic EAT assessment in CT.
Methods: Contrast-enhanced ECG-gated cardiac and thoraco-abdominal spiral CT imaging from 1502 patients undergoing transcatheter aortic valve replacement (TAVR) was included.
Langmuir
December 2024
Department of Physical Chemistry, Faculty of Basic Science, Tarbiat Modares University, P.O. Box 14115-175, Tehran 21, I.R. of Iran.
The aim of this research is to explore the effectiveness of epoxy-resin@polypyrole composites as a corrosion inhibitor when applied as a coating on carbon steel 1018 in a 3.5 wt % sodium chloride electrolyte solution. The anticorrosion properties of these composite coatings can be optimized by manipulating their morphology.
View Article and Find Full Text PDFPhotoacoustics
October 2024
School of Biomedical Engineering, Southern Medical University, Guangzhou, China.
Multispectral photoacoustic tomography (PAT) is an imaging modality that utilizes the photoacoustic effect to achieve non-invasive and high-contrast imaging of internal tissues but also molecular functional information derived from multi-spectral measurements. However, the hardware cost and computational demand of a multispectral PAT system consisting of up to thousands of detectors are huge. To address this challenge, we propose an ultra-sparse spiral sampling strategy for multispectral PAT, which we named U3S-PAT.
View Article and Find Full Text PDFMicrosc Res Tech
December 2024
Department of Pharmacy, COMSATS University Islamabad, Abbottabad, Khyber Pakhtunkhwa, Pakistan.
Traditional medicinal systems have extensively used Primula macrophylla (Primulaceae) to treat a variety conditions, including bronchitis, asthma, joint pain, fever and so forth. This study determines various pharmacognostic and phytochemical standards helpful to ensure the purity, safety, and efficacy of medicinal plant P. macrophylla.
View Article and Find Full Text PDFPhys Rev Lett
November 2024
Nantes Université, INSERM, l'institut du thorax, F-44000 Nantes, France.
Self-organizing spiral electrical waves are produced in the heart during fatal cardiac arrhythmias. Controlling these waves is therefore an essential step in managing the disease. Here we present an effective method for controlling cardiac spiral waves using optogenetics.
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