Cytosine is an essential chemical molecule in living systems, such as DNA and RNA, it is essential in astrobiology to study how it behaves under probable primitive conditions. We looked at how cytosine broke down in aqueous solutions exposed to high radiation levels to learn more about how stable it might have been on the early Earth. We conducted various types of analysis, such as ultraviolet-visible spectroscopy and high-pressure liquid chromatography. We also developed a computer model to describe the kinetic processes and learn more about the molecules involved in the system. This model fits the results of experiments and lets us study cytosine's stability when it is exposed to gamma radiation. It enables researchers to theorize processes that are hard to test in the laboratory and is essential for studying how stable cytosine behaves in high-radiation settings.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639739 | PMC |
http://dx.doi.org/10.1016/j.heliyon.2024.e33288 | DOI Listing |
J Transl Med
January 2025
Department of Radiation Oncology, The Second Affiliated Hospital of Dalian Medical University, No. 467 of Zhongshan Road, Shahekou District, Dalian, 116023, China.
Objective: Cervical cancer is a common malignancy among women, and radiotherapy remains a primary treatment modality across all disease stages. However, resistance to radiotherapy frequently results in treatment failure, highlighting the need to identify novel therapeutic targets to improve clinical outcomes.
Methods: The expression of molecule interacting with CasL-2 (MICAL2) was confirmed in cervical cancer tissues and cell lines through western blotting (WB) and immunohistochemistry (IHC).
BMC Oral Health
January 2025
Associate Professor of Operative Dentistry, Conservative Dentistry Department, Faculty of Oral and Dental Medicine Badr University in Cairo, Cairo, Egypt.
Background: Endodontic treatment aims in the preservation of extremely carious primary teeth. For root canal therapy to be successful, root canals must be properly prepared and effectively irrigated .Therefore, it is necessary to select the proper root canal disinfection method to preserve the primary tooth.
View Article and Find Full Text PDFJ Environ Radioact
January 2025
Hama Agricultural Regeneration Research Centre, Fukushima Agricultural Technology Center, Minami-soma, Fukushima, 975-0036, Japan.
Radioactive cesium released into the atmosphere caused by the Fukushima Dai-ichi Nuclear Power Plant accident in March 2011 has contaminated the surrounding area. We confirmed the applicability of in-situ methods to evaluate the depth distribution of Cs by employing the ratio of Compton-scattering and photo-peak components (r) obtained from measured gamma-ray spectra. In the present study, we applied the in-situ method to farmlands in Fukushima Prefecture whose sites were disturbed by decontamination and plowing operations.
View Article and Find Full Text PDFSensors (Basel)
December 2024
China Institute of Atomic Energy, P.O. Box 275 (26), Beijing 102413, China.
Fast-neutron reactors are an important representative of Generation IV nuclear reactors, and due to the unique structure and material properties of fast reactor fuel, traditional mechanical cutting methods are not applicable. In contrast, laser cutting has emerged as an ideal alternative. However, ensuring the stability of optical fibers and laser cutting heads under high radiation doses, as well as maintaining cutting quality after irradiation, remains a significant technical challenge.
View Article and Find Full Text PDFCancers (Basel)
December 2024
Department of Neurological Surgery, Houston Methodist Neurological Institute, Houston Methodist Hospital, Houston, TX 77030, USA.
Radiation has been used to treat meningiomas since the mid-1970s. Traditionally, radiation was reserved for patients unfit for major surgery or those with surgically inaccessible tumors. With an increased quantity and quality of imaging, and an aging population, there has been a rise in incidentally diagnosed meningiomas with smaller tumors at diagnosis time.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!