Relevance of macrophages in the wound healing process among individuals afflicted with diabetic foot ulcers.

World J Diabetes

Department of Endocrinology & Metabolism, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.

Published: December 2024

In this paper, we provide a commentary on an article focusing on diabetic foot ulcer (DFU) as a dreadful complication of diabetes mellitus. The development of this condition is influenced by factors such as diabetic peripheral neuropathy, lower extremity artery disease, and infection. However, the underlying mechanism remains elusive. Macrophages play a critical role in wound healing processes, suggesting that therapies targeting these cells could potentially improve the management of DFU. A comprehensive understanding of developmental trends of macrophages within the field of DFU may facilitate research advancements and the development of novel treatment strategies.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11580593PMC
http://dx.doi.org/10.4239/wjd.v15.i12.2384DOI Listing

Publication Analysis

Top Keywords

wound healing
8
diabetic foot
8
relevance macrophages
4
macrophages wound
4
healing process
4
process individuals
4
individuals afflicted
4
afflicted diabetic
4
foot ulcers
4
ulcers paper
4

Similar Publications

Exploring the Role of Ccn3 in Type III Cell of Mice Taste Buds.

J Neurochem

January 2025

Department of Oral Physiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.

Different taste cells express unique cell-type markers, enabling researchers to distinguish them and study their functional differentiation. Using single-cell RNA-Seq of taste cells in mouse fungiform papillae, we found that Cellular Communication Network Factor 3 (Ccn3) was highly expressed in Type III taste cells but not in Type II taste cells. Ccn3 is a protein-coding gene involved in various biological processes, such as cell proliferation, angiogenesis, tumorigenesis, and wound healing.

View Article and Find Full Text PDF

Screening and identification of antimicrobial peptides from the gut microbiome of cockroach Blattella germanica.

Microbiome

December 2024

MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian, Liaoning, 116024, China.

Article Synopsis
  • * Researchers identified and validated an AMP, named AMP1, which has broad-spectrum antibacterial activity and minimal toxicity to human cells, showing potential as a safer alternative to traditional antibiotics.
  • * The study emphasizes the effective screening of natural AMPs and highlights AMP1's ability to affect bacterial cell wall synthesis and promote wound healing, suggesting it could be a viable option for clinical use.
View Article and Find Full Text PDF

Background: Periodontitis is a chronic inflammatory disease caused by the accumulation of biofilm. Antimicrobials have been used as adjuncts to non-surgical periodontal therapy. However, systemic antibiotics often require large dosages to achieve suitable concentrations at the disease site.

View Article and Find Full Text PDF

Background: Acute postoperative pain is often reported after repair of inguinal hernia and can negatively impact patient satisfaction and clinical outcomes. This includes delayed wound healing, longer hospitalization, and increased health care costs. Non-pharmacological techniques like Progressive Muscle Relaxation (PMR) and Rhythmic Breathing (RB) have been suggested as possible interventions for managing this type of pain.

View Article and Find Full Text PDF

Foam-based wound dressing materials produced by dispersing gas phases in a polymeric material are soft, adapt to the body shape, and allow the absorption of wound exudate due to their porous structure. Most of these formulations are based on synthetic substances such as polyurethane. However, biopolymers have entered the field as a new player thanks to their biocompatible and sustainable nature.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!