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Real-world effectiveness and causal mediation study of BNT162b2 on long COVID risks in children and adolescents.
EClinicalMedicine
January 2025
Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Background: The impact of pre-infection vaccination on the risk of long COVID remains unclear in the pediatric population. We aim to assess the effectiveness of BNT162b2 on long COVID risks with various strains of the SARS-CoV-2 virus in children and adolescents, using comparative effectiveness methods. We further explore if such pre-infection vaccination can mitigate the risk of long COVID beyond its established protective benefits against SARS-CoV-2 infection using causal mediation analysis.
View Article and Find Full Text PDFPrioritizing cases from a multi-institutional cohort for a dataset of pathologist annotations.
J Pathol Inform
January 2025
U.S. Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Imaging, Diagnostics, and Software Reliability, Silver Spring, MD, United States of America.
Objective: With the increasing energy surrounding the development of artificial intelligence and machine learning (AI/ML) models, the use of the same external validation dataset by various developers allows for a direct comparison of model performance. Through our High Throughput Truthing project, we are creating a validation dataset for AI/ML models trained in the assessment of stromal tumor-infiltrating lymphocytes (sTILs) in triple negative breast cancer (TNBC).
Materials And Methods: We obtained clinical metadata for hematoxylin and eosin-stained glass slides and corresponding scanned whole slide images (WSIs) of TNBC core biopsies from two US academic medical centers.
Expanding the landscape of tricuspid regurgitation with transcatheter tricuspid valve replacement.
Int J Cardiol Heart Vasc
February 2025
Conemaugh Health System, 1086 Franklin Street, Johnstown, 15905, PA, USA.
Atrial fibrillation does not equal atrial fibrillation: The important prognostic implications of new-onset atrial fibrillation.
Int J Cardiol Heart Vasc
February 2025
Institute of Pharmacology, West-German Heart and Vascular Centre, University Duisburg-Essen, Essen, Germany.
MASLD, MLA Pesarattu and Other Developments.
J Clin Exp Hepatol
November 2024
Department of Gastroenterology & Hepatology, Kalinga Institute of Medical Sciences, Bhubneshwar, India.
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