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http://dx.doi.org/10.1016/j.euf.2024.10.012 | DOI Listing |
Eur J Nutr
December 2024
Department of Epidemiology, Maastricht University, Universiteitssingel 40 (Room C5.570), Maastricht, 6229 ER, The Netherlands.
Purpose: Although total dietary protein intake has been associated with bladder cancer (BC) risk, the effect of the origin (plant or animal) and the substitutions remain to be understood. This study aimed to investigate the effect of total dietary protein, animal-based protein, plant-based protein, and their substitutions with each other on the risk of BC using a pooled analysis of 10 cohort studies.
Methods: The study was conducted within the "BLadder cancer Epidemiology and Nutritional Determinants" (BLEND) study, including 10 prospective cohort studies from several European countries, the United Kingdom, and the United States.
Eur Urol Focus
December 2024
Department of Urology, Città della Salute e della Scienza, University of Torino School of Medicine, Torino, Italy.
Scand J Urol
October 2024
Institution of Translational Medicine, Lund University, Malmö, Sweden; Department of Urology Skåne University Hospital, Malmö, Sweden.
N/A.
View Article and Find Full Text PDFJCO Precis Oncol
October 2024
Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.
Purpose: Cisplatin-based combination chemotherapy (CHT) is standard of care in metastatic urothelial cancer (mUC); however, no predictive molecular biomarkers are available for clinical use. The aim of this study was to investigate the impact of molecular subtypes in relation to treatment response and survival in patients with mUC treated with first-line CHT.
Patients And Methods: Molecular subtype classification according to the Lund Taxonomy (LundTax) was performed by tumor transcriptomic profiling and immunostaining in a retrospective cohort.
Eur Urol Oncol
September 2024
Department of Urology, Città della Salute e della Scienza, University of Torino School of Medicine, Torino, Italy.
Although high-level evidence is currently lacking, noninferiority randomised controlled trials in predefined risk groups in non-muscle-invasive bladder cancer are under way to scientifically prove the safety of urinary biomarker-guided follow-up. To facilitate recommendations for clinical use, it is essential to comply with the EU certification for in vitro diagnostics and to demonstrate cost effectiveness.
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