Background: The management of pharmacy services within healthcare institutions presents significant challenges, particularly in ensuring the rational use of medications. These challenges include managing complex medication regimens and ensuring patient safety amidst a growing number of drug interactions.
Objective: This study aimed to construct a hospital pharmacy service competence assessment model focused on the promoting the rational use of medications so as to enable hospitals to assess their pharmacy services more accurately and efficiently.
Methods: A three-step methodology was employed to identify the indicators for assessing hospital pharmacy service capabilities. First, the Delphi method was used to select the initial indicators. Second, an assessment model was developed through principal component analysis (PCA) by incorporating the selected indicators. Third, this model was applied in a comprehensive field assessment involving our hospital and 194 others throughout the Shanxi province, China.
Results: The screening process identified 10 primary indicators and 53 secondary indicators encompassing key areas such as rational clinical medication management, informatics, infrastructure development, and the expansion of pharmacy services. The resulting hospital pharmacy service competence assessment model was applied to 195 hospitals of varied tiers, with the assigned scores (x‾ = 36.12) employed to conduct a comprehensive evaluation and identify areas requiring targeted intervention to optimize pharmacy services in each hospital.
Conclusion: We established a comprehensive assessment model that reflects the competency of hospital pharmacy services from a management perspective. The model integrates the strategic approach of rational medication use, providing robust support for healthcare organizations in assessing pharmacy service capacity and improving the management of rational use.
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http://dx.doi.org/10.1016/j.sapharm.2024.12.002 | DOI Listing |
J Pharm Pharmacol
January 2025
Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Objectives: PD15, a novel natural steroidal saponin extracted from the rhizomes of Paris delavayi Franchet, has demonstrated a strong cytotoxic effect against HepG2 and U87MG cells. However, its therapeutic effects on colorectal cancer (CRC) and the underlying molecular mechanisms remain unclear.
Methods: MTT assay, clonogenic assay, Hoechst 33258 staining, flow cytometry, molecular docking, and western blot were used to investigate the mechanism of PD15 in HCT116 cell lines.
Neurology
February 2025
School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Background And Objectives: Lipid metabolism in older adults is affected by various factors including biological aging, functional decline, reduced physiologic reserve, and nutrient intake. The dysregulation of lipid metabolism could adversely affect brain health. This study investigated the association between year-to-year intraindividual lipid variability and subsequent risk of cognitive decline and dementia in community-dwelling older adults.
View Article and Find Full Text PDFJ Mol Med (Berl)
January 2025
Hospital Sensory Department, Shenzhen Qianhai Shekou Free Trade Zone Hospital, 36 Gongye Qi Road, Nanshan District, Shenzhen, 518067, China.
This work researched the influence and mechanism of CD155 on hepatocellular carcinoma advancement. CD155 expression and its effect on survival of hepatocellular carcinoma patients were analyzed based on the GEPIA2 database. String software predicted the interacting between CD155 and CD96, which was further verified by co-immunoprecipitation experiment.
View Article and Find Full Text PDFPain Ther
January 2025
Department of Trauma and Orthopaedic Surgery, Faculty of Medicine and Psychology, University La Sapienza, 00185, Rome, Italy.
Introduction: Elbow ailments are common, but conventional treatment modalities have shortcomings, offering only interim pain relief rather than targeting the underlying pathophysiology. The last two decades have seen a marked increase in the use of autologous peripheral blood-derived orthobiologics (APBOs), such as platelet-rich plasma (PRP), to manage elbow disorders. Platelet-rich plasma (PRP) is the most widely used APBO, but its efficacy remains debatable.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
January 2025
Division of Nephrology, Faculty of Medicine, Department of Internal Medicine, Suleyman Demirel University, Isparta, Turkey.
The kidneys have a regulatory role in many diseases with their diuresis function and capacity to maintain electrolyte balance. In case of extensive damage, the kidney's filtration capacity is impaired and cannot fulfill its functions. Fluvoxamine (FLV), an antidepressant agent, has antioxidant and anti-inflammatory effects.
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