Tibial fractures are common long bone injuries requiring effective monitoring for optimal healing. Osteoprotegerin (OPG), as a key marker of bone formation, is closely related to the degree of fracture healing. However, existing detection methods have certain limitations in sensitivity and specificity. This study successfully crafted an exceptionally sensitive electrochemical immunosensor based on COOH-CNFs/TiCT MXene/PANI-AgNPs nanocomposite material for the quantitative analysis of OPG in serum, providing a methodological basis for auxiliary diagnosis of fracture healing degree and evaluation of drug efficacy. A one-pot hydrothermal method was employed to synthesize and modify the nanocomposite material on gold electrode surfaces, which exhibit high electrochemical activity, low charge transfer resistance, and a large electroactive surface area, thereby enhancing the immunosensor's conductivity and stability, with a wide linear range (10 to 10 g/mL) and a low detection limit (1.94 × 10 g/mL). Methodological validation further confirmed the immunosensor's excellent performance in specificity, reproducibility, and stability. Moreover, the successful application of this immunosensor in detecting OPG in serum samples from actual tibial fracture patients before and after medication demonstrates significant potential for clinical application in assisting the assessment of fracture healing and evaluating the efficacy of orthopedic drugs.
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http://dx.doi.org/10.1016/j.bioelechem.2024.108884 | DOI Listing |
Arch Orthop Trauma Surg
December 2024
Department of Thoracic Surgery, The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Objective: The objective of this study was to evaluate the short-term outcomes of single-port thoracoscopic rib fracture reduction and internal fixation for the treatment of multiple rib fractures.
Methods: This study included 149 patients with multiple rib fractures admitted to the Second People's Hospital Affiliated with Fujian University of Chinese Medicine between June 2021 and April 2024. The patients were divided into two groups based on the surgical method.
World J Surg Oncol
December 2024
Department of Orthopaedic Surgery, Sarcoma Unit, St Vincent's Hospital Melbourne, 41 Victoria Parade, Fitzroy, VIC, 3065, Australia.
Background: Post-radiation fractures (PRF) are a recognised complication of radiation treatment for soft tissue sarcomas. They have a low incidence and typically occur up to 5 years following treatment, more commonly affecting the pelvis, ribs and femur. Due to radiation-induced changes in bone, PRFs typically require more complicated intervention compared to post-trauma fractures, however, limited literature exists, particularly in regards to mid-shaft femoral PRFs.
View Article and Find Full Text PDFJ Neurosurg Spine
December 2024
2Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland; and.
Objective: There is a paucity of high-quality return-to-play (RTP) data following treatment of cervical spine injuries in contact sports. In this study, the authors gathered insights from National Football League (NFL) team spine surgeon consultants to highlight current practices in treating cervical spine injuries and report decision-making regarding RTP in professional American football players.
Methods: A cross-sectional, online survey was distributed to all NFL consulting physicians specializing in the management of spine injuries.
Medicine (Baltimore)
December 2024
Department of Ultrasound, Peking University First Hospital - MiYun Hospital, Beijing, China.
Rib fractures are a common injury following blunt chest trauma, accounting for approximately 10% of all traumatic injuries and up to 50% of blunt chest trauma cases. These fractures are associated with a high risk of complications, such as pneumothorax, hemothorax, and pulmonary infections, and can significantly impact respiratory function. This study analyzes the risk factors for poor healing and long-duration pain in the conservative treatment of rib fractures, providing a reference for clinicians in choosing conservative treatment and formulating treatment plans.
View Article and Find Full Text PDFStomatologiia (Mosk)
December 2024
Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia.
The main principles of management of children with root fractures of permanent teeth in the coronal third are presented using two clinical cases as an example. In the treatment of root fractures in the coronal third, an important condition for success is timely flexible or semi-flexible splinting of the tooth for a sufficiently long period (up to 4 months). In the absence of splinting or significant mobility of the coronal fragment after removal of the splint the probability of pulp necrosis is very high, and the method of choice is treatment with calcium silicate cements with their introduction by orthograde or surgical access.
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