Potent phytoceuticals cocktail exhibits anti-inflammatory and antioxidant activity on LPS-triggered RAW264.7 macrophages in vitro.

Pathol Res Pract

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW 2007, Australia; Faculty of Health, Australian Research Consortium in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia. Electronic address:

Published: December 2024

Chronic inflammatory conditions, which include respiratory diseases and other ailments, are characterized by persistent inflammation and oxidative stress, and represent a significant health burden, often inadequately managed by current therapies which include conventional inhaled bronchodilators and oral or inhaled corticosteroids in the case of respiratory disorders. The present study explores the potential of Vedicinals®9 Advanced, a polyherbal formulation, to mitigate LPS-induced inflammation and oxidative stress in RAW264.7 mouse macrophages. The cells were pre-treated with Vedicinals®9 Advanced, followed by exposure to LPS to induce an inflammatory response. Key experimental outcomes were assessed, including nitric oxide (NO) and reactive oxygen species (ROS) production, as well as the expression of inflammatory and oxidative stress-related genes and proteins. Vedicinals®9 Advanced significantly reduced LPS-induced NO and ROS production, indicating strong anti-inflammatory and antioxidant properties. Additionally, the formulation downregulated the LPS-upregulated mRNA expression of pro-inflammatory cytokines, such as TNF-α and CXCL1, and oxidative stress markers, including GSTP1 and NQO1. Furthermore, Vedicinals®9 Advanced downregulated the LPS-induced protein expression of the chemokines CCL2 and CCL6, the LPS co-receptor, CD14, and the pro-inflammatory cytokines G-CSF and IL-1β. These findings highlight the potential of Vedicinals®9 Advanced as a therapeutic option for managing CRDs and other inflammatory conditions. The formulation's ability to simultaneously target inflammation and oxidative stress suggests it may offer advantages over existing treatments, with potential for broader application in inflammatory diseases.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.prp.2024.155770DOI Listing

Publication Analysis

Top Keywords

vedicinals®9 advanced
20
oxidative stress
16
inflammation oxidative
12
anti-inflammatory antioxidant
8
inflammatory conditions
8
potential vedicinals®9
8
ros production
8
pro-inflammatory cytokines
8
inflammatory
5
oxidative
5

Similar Publications

Validity and Reliability of the Turkish Version of the Environmental Health Literacy Scale.

J Eval Clin Pract

February 2025

Faculty of Health Sciences, Department of Nursing, Division of Public Health Nursing, Bandırma Onyedi Eylül University, Balıkesir, Turkey.

Aim: This study aimed to translate the Environmental Health Literacy Scale (EHLS) into Turkish and assess its construct validity and internal consistency.

Methods: This research employs a methodological design. The research was conducted during the 2022-2023 academic year with a sample of 500 students from the Faculty of Health Sciences.

View Article and Find Full Text PDF

With the advancement of precise hepatobiliary surgery concepts, the diagnostic and therapeutic approaches for hepatic echinococcosis have undergone significant transformations. However, whether these changes have correspondingly improved patient outcomes remains unclear. A retrospective analysis of these changes will provide crucial guidance for the prevention and treatment of hepatic echinococcosis.

View Article and Find Full Text PDF

The emergence of self-propelling magnetic nanobots represents a significant advancement in the field of drug delivery. These magneto-nanobots offer precise control over drug targeting and possess the capability to navigate deep into tumor tissues, thereby addressing multiple challenges associated with conventional cancer therapies. Here, Fe-GSH-Protein-Dox, a novel self-propelling magnetic nanobot conjugated with a biocompatible protein surface and loaded with doxorubicin for the treatment of triple-negative breast cancer (TNBC), is reported.

View Article and Find Full Text PDF

A corpus of Chinese word segmentation agreement.

Behav Res Methods

December 2024

Department of Education Studies, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong.

The absence of explicit word boundaries is a distinctive characteristic of Chinese script, setting it apart from most alphabetic scripts, leading to word boundary disagreement among readers. Previous studies have examined how this feature may influence reading performance. However, further investigations are required to generate more ecologically valid and generalizable findings.

View Article and Find Full Text PDF

Accurate characterisation of seismic source mechanisms in mining environments is crucial for effective hazard mitigation, but it is complicated by the presence of anisotropic geological conditions. Neglecting anisotropic effects during moment tensor (MT) inversion introduces significant distortions in the retrieved source characteristics. In this study, we investigated the impact of ignoring anisotropy during MT inversion on the reliability of hazard assessment.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!