Previous studies found red-edge tea polysaccharides (RETPS)-3 and 4 have anti-allergic effects. To investigate the anti-food allergy activity of the RETPS-3/4, the ovalbumin-induced Balb/c mouse food allergy model was established. Food allergy symptoms, serum inflammatory factors, spleen and intestinal pathology were analyzed. The proportion of lymphocyte clusters was measured by flow cytometry. The intestinal flora of mice was examined using the 16S rDNA method. The results showed that RETPS-3/4 alleviated food allergy symptoms in mice, relieved intestinal injury, and reduced the contents of ovalbumin-specific immunoglobulin E, mast cell protease, and histamine in the serum of mice. In addition, RETPS-3/4 regulated the proportion of Th2 cells in mouse mesenteric lymph nodes and the abundance of Lactobacillus_muris and Prevotella. These results showed that RETPS-3/4 had anti-food allergy activity and could be developed as a functional anti-food allergy product.
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