AI Article Synopsis
- - The study aimed to explore the effects of maternal epilepsy on pregnancy, delivery, and neonatal outcomes by analyzing data from a large cohort of pregnancies between 2004 and 2014.
- - Women with epilepsy were found to have a higher prevalence of other health issues (e.g., obesity and gestational diabetes) and demographic characteristics indicating lower income and higher insurance coverage through Medicaid or Medicare.
- - Results indicated that pregnant women with epilepsy faced significantly higher risks for various complications, including preeclampsia, preterm delivery, and even maternal death, underscoring the need for targeted medical support during pregnancy.
Article Abstract
Objective: To investigate associations between maternal epilepsy and pregnancy, delivery and neonatal outcomes.
Methods: A population-based retrospective cohort study was conducted using the Healthcare Cost and Utilization Project, Nationwide Inpatient Sample (HCUP-NIS) database, between 2004-2014. Through logistic regression analysis, we compared associations between epilepsy and pregnancy-related outcomes while adjusting for demographic characteristics and comorbidities.
Results: Of 9,096,788 pregnancies, 25,044 were in pregnant women with epilepsy (PWWE). PWWE were more likely to be younger, white or black, have a lower income and to be insured through Medicare or Medicaid. Furthermore, PWWE were more likely to have been diagnosed with obesity, chronic hypertension, gestational diabetes, thyroid disease and HIV, and to have smoked tobacco during pregnancy or used illicit drugs. Pregnancy and delivery outcomes associated with epilepsy include pregnancy-induced hypertension(adjusted OR(aOR):1.26, 95 %CI:1.21-1.32), preeclampsia(aOR:1.33, 95 %CI:1.26-1.41), eclampsia(aOR:8.34, 95 %CI:7.14-9.74), superimposed preeclampsia/eclampsia(aOR:1.29, 95 %CI:1.14-1.47), placenta previa(aOR:1.24, 95 %CI:1.06-1.44), preterm delivery(aOR:1.27, 95 %CI:1.21-1.32), abruptio placenta(aOR:1.24, 95 %CI:1.12-1.36), chorioamnionitis(aOR:1.12, 95 %CI:1.02-1.23), cesarean section(aOR:1.29, 95 %CI:1.25-1.33), hysterectomy(aOR:1.79, 95 %CI:1.31-2.45), postpartum hemorrhage(aOR:1.12, 95 %CI:1.05-1.21), wound complications(aOR:1.38, 95 %CI:1.17-1.63), maternal death(aOR:3.42, 95 %CI:1.79-6.53), transfusion(aOR:1.67, 95 %CI:1.53-1.83), maternal infection(aOR:1.18, 95 % CI:1.09-1.28, p < 0.001), deep vein thrombosis(aOR:2.11, 95 %CI:1.43-3.10), pulmonary embolism(aOR:2.98, 95 %CI:1.87-4.76), venous thromboembolism(aOR:2.25, 95 %CI:1.65-3.08) and disseminated intravascular coagulation(aOR:1.48, 95 %CI:1.19-1.83). Epilepsy-linked neonatal complications include small for gestational age(aOR:1.52, 95 %CI:1.43-1.62), intrauterine fetal demise(aOR:1.20, 95 %CI:1.02-1.41) and congenital anomalies(aOR:2.76, 95 %CI:2.47-3.07).
Conclusions: PWWE have significantly higher risk of nearly every pregnancy, delivery and neonatal complication investigated, including maternal death and intrauterine fetal demise. PWWE should be considered high risk patients and be carefully followed during pregnancy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.yebeh.2024.110221 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: With the COVID-19 emergency, the provision of healthcare had to be reorganized. Community Health Services for Families of Trieste adopted new methods to ensure continuity of care and the maintenance of the Standards and Good Practices of the Baby Friendly Initiative of UNICEF for the Birth Care Pathway. The aim of the study was to identify the perceived needs of women, couples, caregivers, and health professionals during the COVID-19 pandemic and evaluate new healthcare strategies, identifying weaknesses and strengths, and future developments.
View Article and Find Full Text PDFEvaluation of the effect of rozanolixizumab on pregnancy outcomes and pre- and postnatal development in cynomolgus monkeys.
Reprod Toxicol
December 2024
Labcorp, Münster, Germany.
Rozanolixizumab, a humanised immunoglobulin (Ig) G4 monoclonal antibody that selectively inhibits binding of IgG to the neonatal Fc receptor (FcRn), was evaluated in an embryo-foetal enhanced pre- and postnatal development (ePPND) study. Pregnant female cynomolgus monkeys (19 per group) received subcutaneous rozanolixizumab 50mg/kg or 150mg/kg or vehicle every 3 days from gestation day 20 until delivery. The proportion of pregnancy losses was 15.
View Article and Find Full Text PDFMaternal Characteristics and Pregnancy Outcomes Associated with Delivery versus Expectant Management following Decreased Fetal Movement at Term.
Am J Perinatol
December 2024
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut.
Objective: This study aimed to compare maternal characteristics and pregnancy outcomes between term patients evaluated for decreased fetal movement (DFM) who were delivered versus expectantly managed.
Study Design: Retrospective cohort study of term patients delivering within a large hospital system from 2015 to 2023 who were evaluated for DFM. Patients were classified into three groups based on the time between evaluation for DFM and delivery admission: (1) <24 hours, (2) 24-48 hours, (3) >48 hours.
Development and internal validation of a model predicting successful trial of labour among pregnant individuals with previous one caesarean section: A cohort study (DEVI-CS model).
Eur J Obstet Gynecol Reprod Biol
December 2024
Department of Obstetrics & Gynaecology, Jawaharlal Institute of Medical Education & Research, Puducherry 605006, India. Electronic address:
Objective: To develop and internally validate a model predicting successful trial of labour among pregnant women with previous caesarean scar.
Design: Cohort study.
Setting: Tertiary care and teaching hospital.
Late gestation heat stress alters O regulation in placenta and neonatal heifers.
Placenta
December 2024
Department of Animal Sciences, University of Florida, Gainesville, USA. Electronic address:
Introduction: Maternal hyperthermia (i.e. heat stress) can adversely affect placental development and function, with severity varying based on pregnancy stage.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!