AI Article Synopsis
- Pituitary tumors (PTs) are common benign tumors, and analyzing serum and cerebrospinal fluid metabolites is crucial for understanding their biology and identifying potential biomarkers and treatments.
- The research used datasets from FinnGen and GWAS to identify correlations between 27 metabolites and PTs, applying various methods for robust analysis, including inverse variance weighting and multiple sensitivity tests.
- Notably, 3-dehydrocarnitine and acetylcarnitine were highlighted as significant factors related to PTs, with strong statistical evidence for their roles, and no reverse causality was found between these metabolites and PTs.
Article Abstract
Background: Pituitary tumors (PTs) are common benign intracranial tumors. Investigating the metabolites in serum and cerebrospinal fluid in PTs is essential to understanding the underlying biological mechanisms and identifying new biomarkers and therapeutic strategies.
Methods: We used the GWAS dataset of PTs from the FinnGen database, a dataset of 486 plasma metabolites from the GWAS catalog database, and a dataset of 338 cerebrospinal fluid (CSF) metabolites from the WADRC and WRAP study collections. An inverse variance weighting (IVW) approach was utilized as the mainly method to investigate causality between metabolites and PTs, supplemented by four complementary methods to strengthen our findings. Additionally, we utilized several sensitivity methods to guarantee the robustness of our findings.
Results: The study identified 17 plasma metabolites and 10 CSF metabolites related to PTs. Among these, 11 metabolites indicated a significant positive causality with PTs, while 16 displayed a remarkable negative causality. Particularly, plasma levels of 3-dehydrocarnitine (OR = 2.73, 95% CI = 1.55-4.83, P = 0.001) and acetylcarnitine (OR = 0.35, 95% CI = 0.19-0.63, P = 0.001) were found to be significant exposure factors for PTs. Multiple sensitivity analyses confirm the robustness of the results. The study found no evidence of a reverse causality between PTs and the plasma levels of 3-dehydrocarnitine and acetylcarnitine.
Conclusions: The present study identified 27 metabolites associated with the incidence of PTs, among which 3-dehydrocarnitine and acetylcarnitine are the most noteworthy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634583 | PMC |
| http://dx.doi.org/10.3389/fendo.2024.1460278 | DOI Listing |
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