AI Article Synopsis
- The study examines the effectiveness of stent implantation for complex coronary artery disease (CAD), comparing procedures guided by intravascular ultrasound (IVUS) to those without IVUS guidance.
- Researchers analyzed data from six randomized control trials involving 5,173 subjects, finding that IVUS guidance significantly reduced major adverse cardiovascular events, cardiac death, target vessel revascularization, target lesion revascularization, and stent thrombosis.
- However, there was no significant difference in the rates of myocardial infarction and all-cause death between the two groups, suggesting IVUS may enhance the safety and efficacy of stent placement in complex CAD cases.
Article Abstract
Background: This study is to investigate the efficacy of stent implantation in patients with complex coronary artery disease (CAD) under intravascular ultrasound (IVUS) guidance and non-IVUS guidance.
Methods: We conducted a systematic search in PubMed, Web of Science, Cochran, and Embase for the articles of IVUS-guided and non-IVUS-guided stent implantation in patients with complex CAD and reported related outcomes. We included major adverse cardiovascular events (MACE), myocardial infarction (MI), cardiac death and other outcome indicators. Relative ratio (RR) and 95% confidence interval (CI) were used for statistical analysis.
Results: A total of 5,173 subjects were included in 6 randomized control trials. The results showed that the incidence of MACE (RR: 0.63, 95% CI: 0.49-0.82, < 0.001), cardiac death (RR: 0.61, 95% CI: 0.44-0.85, = 0.004), target vessel revascularization (TVR) ( = 0.01), target lesion revascularization (TLR) ( = 0.03) and stent thrombosis (ST) ( = 0.002) in the experimental group (IVUS-guidance) was lower than that in the control group (non-IVUS-guidance). However, no statistical difference was observed between the both groups in the incidence of MI ( = 0.13) and all-cause death ( = 0.41).
Conclusions: Compared with the non-IVUS-guided group, IVUS-guided stent implantation may be more effective for patients with complex CAD.
Systematic Review Registration: PROSPERO [CRD42024531366].
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634805 | PMC |
| http://dx.doi.org/10.3389/fcvm.2024.1446014 | DOI Listing |
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