Three calcium channel blockers of the dihydropyridine class were tested in vitro for their effects on tumor cell-platelet-endothelial cell interactions and in vivo for antimetastatic properties. Felodipine, nimodipine and nifedipine inhibited tumor cell-induced platelet aggregation in vitro in a dose-dependent manner. These compounds also inhibited platelet-enhanced tumor cell adhesion to endothelial cells in vitro. Lung colony formation ("experimental" metastasis) and spontaneous pulmonary metastasis were inhibited by felodipine, nimodipine and nifedipine. From the present studies on three calcium channel blockers of the dihydropyridine class we hypothesize that calcium channel blockers may represent a new generic class of antimetastatic agents.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0006-2952(85)90130-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Updating probability of pathogenicity for RYR1 and CACNA1S exon variants in individuals without malignant hyperthermia after exposure to triggering anesthetics.
Pharmacogenet Genomics
February 2025
Department of Anesthesiology, Vanderbilt University Medical Center.
Objectives: We aimed to classify genetic variants in RYR1 and CACNA1S associated with malignant hyperthermia using biobank genotyping data in patients exposed to triggering anesthetics without malignant hyperthermia phenotype.
Methods: We identified individuals who underwent surgery and were exposed to triggering anesthetics without malignant hyperthermia phenotype and who had RYR1 or CACNA1S genotyping data available in our biobank. We classified all variants in the cohort using a Bayesian framework of the American College of Medical Genetics and Genomics and the Association of Molecular Pathologists guidelines for variant classification and updated the posterior probabilities from this model with the new information from our biobank cohort.
Investigating the Role of TRPV4 and GPR35 Interaction in Endothelial Dysfunction in Aging Mice.
Aging Cell
January 2025
Wuxi School of Medicine, Jiangnan University, Wuxi, China.
Endothelial dysfunction, characterized by a decline in endothelial physiological functions, is a significant aspect of cardiovascular aging, contributing notably to arterial stiffness, atherosclerosis, and hypertension. Transient receptor potential channel V4 (TRPV4), a key member of Ca-permeable channels, plays a crucial role in maintaining vascular functions. However, the role and mechanisms of TRPV4 in aging-related endothelial dysfunction remain incompletely understood.
View Article and Find Full Text PDFTargeting ion channels: innovative approaches to combat cancer drug resistance.
Theranostics
January 2025
School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Ion channels, as functional molecules that regulate the flow of ions across cell membranes, have emerged as a promising target in cancer therapy due to their pivotal roles in cell proliferation, metastasis, apoptosis, drug resistance, and so on. Recently, increasing evidence suggests that dysregulation of ion channels is a common characteristic of cancer cells, contributing to their survival and the resistance to conventional therapies. For example, the aberrant expression of sodium (Na) and potassium ion (K) channels is significantly correlated with the sensitivity of chemotherapy drugs.
View Article and Find Full Text PDFThe modulation of calcium and chloride channels induces cardiomyocytes from human pluripotent stem cells.
Int J Biol Sci
January 2025
Faculty of Health Sciences, University of Macau, Taipa, Macau.
Ion channels play a crucial role in cardiac functions, and their activities exhibit dynamic changes during heart development. However, the precise function of ion channels in human heart development remains elusive. In this study, we utilized human embryonic stem cells (hESCs) as a model to mimic the process of human embryonic heart development.
View Article and Find Full Text PDFMineral Scaling in 3D Interfacial Solar Evaporators─A Challenge for Brine Treatment and Lithium Recovery.
Environ Sci Technol
January 2025
Department of Civil and Environmental Engineering, University of California, Berkeley, Berkeley, California 94720, United States.
In this work, we analyzed the effects of mineral scaling on the performance of a 3D interfacial solar evaporator, with a focus on the cations relevant to lithium recovery from brackish water. The field has been rapidly moving toward resource recovery applications from brines with higher cation concentrations. However, the potential complications caused by common minerals in these brines other than NaCl have been largely overlooked.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!