Introduction: Kingella kingae has become an increasingly significant cause of osteoarticular infection in children under the age of 4. The bacteria is infrequent in adults. Previous reports have indicated its association with infections, primarily affecting immunocompromised individuals. Only a few cases of isolated septic knee arthritis in immunocompetent patients caused by K. kingae have been reported.
Case Report: We present a case involving a 64-year-old male with an unremarkable medical history diagnosed with septic arthritis in the knee attributed to K. kingae. He was treated with antibiotic therapy and joint irrigation and discharged with outpatient follow-up on the 9th day. The diagnosis led to an unexpected finding of multiple myeloma prompting further treatment.
Conclusion: This case confirms that K. kingae can cause septic arthritis in adults and physicians and microbiologists should be alert to the possibility, especially in adults with an underlying disease.
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http://dx.doi.org/10.13107/jocr.2024.v14.i12.5020 | DOI Listing |
Background: Diarrhoeal diseases claim more than 1 million lives annually and are a leading cause of death in children younger than 5 years. Comprehensive global estimates of the diarrhoeal disease burden for specific age groups of children younger than 5 years are scarce, and the burden in children older than 5 years and in adults is also understudied. We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to assess the burden of, and trends in, diarrhoeal diseases overall and attributable to 13 pathogens, as well as the contributions of associated risk factors, in children and adults in 204 countries and territories from 1990 to 2021.
View Article and Find Full Text PDFBMC Immunol
December 2024
Immunogenetics Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Epithelial cells (ECs) provide the first line of defense against microbial threats and environmental challenges. They participate in the host's immune responses via the expression and secretion of various immune-related molecules such as cytokines and chemokines, as well as interaction with immune cells. A growing body of evidence suggests that the dysregulated function of ECs can be involved in the pathophysiology of a broad range of infectious, autoimmune, and inflammatory diseases, including inflammatory bowel disease (IBD), asthma, multiple sclerosis, and rheumatoid arthritis.
View Article and Find Full Text PDFPediatr Infect Dis J
December 2024
Division of Infectious Diseases, Department of Pediatrics, Tokyo Metropolitan Children's Medical Center Tokyo, Tokyo, Japan.
An 18-month-old boy presented with septic arthritis and osteomyelitis caused by Hypervirulent Klebsiella pneumoniae harboring cardinal virulence genes. The condition necessitated several surgical interventions, and a prolonged course of antibiotic therapy to effectively manage the severe infection and prevent complications, highlighting the challenges posed by Hypervirulent Klebsiella pneumoniae in pediatric cases.
View Article and Find Full Text PDFFuture Microbiol
December 2024
Department of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
usually presents with erythrasma, a macular rash, but rarely it can cause extracutaneous infections such as endocarditis, peritonitis, pyelonephritis, and catheter-related bloodstream infections. Here, we present the first case of septic arthritis caused by and a literature review of invasive infections. The diagnosis was confirmed by the patient's clinical findings and microbiological examination of the joint fluid.
View Article and Find Full Text PDFJCI Insight
December 2024
Infection Biology Program, Global Center for Pathogen Research and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Patients with immune-mediated inflammatory diseases (IMIDs) like rheumatoid arthritis (RA) are at higher risk for severe COVID-19 and long-term complications in bone health. Emerging clinical evidence demonstrated that SARS-CoV-2 infection reduces bone turnover and promotes bone loss, but the mechanism underlying worsened bone health remains elusive. This study sought to identify specific immune mediators that exacerbated preexisting IMIDs after SARS-CoV-2 exposure.
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