Inspired by biosynthetic peptides, we investigate the chiral recognition properties of adenylate amidate (-aa-AMP, a potential analog of 5'-aa-AMP) in prebiotic peptide formation. Our findings demonstrate that -L-aa-AMP preferentially binds to L-aa, facilitating the formation of homochiral peptides, while -D-aa-AMP shows a preference for D-aa, thereby achieving homochirality in peptide synthesis. Collectively, these results enhance our understanding of the evolutionary origins of homochirality on prebiotic Earth.
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| http://dx.doi.org/10.1039/d4cc05580b | DOI Listing |
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