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Noise - an insidious stressor affecting xenobiotic metabolism?
Xenobiotica
December 2024
Department of Medicine, Imperial College London, London, UK.
Activatable fluorescent probes for atherosclerosis theranostics.
iScience
October 2024
Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan 523808, China.
The onset of atherosclerosis (AS) is insidious, and early stage patients have atypical clinical symptoms. After being diagnosed in late stage, it is often prone to sudden and fatal cardiovascular events. Therefore, it is highly desirable to develop precise and efficient diagnosis and therapy strategies of AS.
View Article and Find Full Text PDFSerum Levels of Stereocilin as a Hearing Biomarker.
Otolaryngol Head Neck Surg
December 2024
Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Connecticut Health, Farmington, Connecticut, USA.
Noise-induced hearing loss (NIHL) often presents with an insidious onset, resulting from the cumulative effect of chronic, high-level noise exposure regardless of etiology. Stereocilin (STRC) is a protein that supports stereocilia attachment and cochlear hair cell function, 2 common targets of noise trauma. In this study, we explored the relationship between STRC and daily noise exposure in young, healthy adults.
View Article and Find Full Text PDFRapid diagnosis of membranous nephropathy based on serum and urine Raman spectroscopy combined with deep learning methods.
Sci Rep
February 2023
College of Software, Xinjiang University, Urumqi, 830046, China.
Membranous nephropathy is the main cause of nephrotic syndrome, which has an insidious onset and may progress to end-stage renal disease with a high mortality rate, such as renal failure and uremia. At present, the diagnosis of membranous nephropathy mainly relies on the clinical manifestations of patients and pathological examination of kidney biopsy, which are expensive, time-consuming, and have certain chance and other disadvantages. Therefore, there is an urgent need to find a rapid, accurate and non-invasive diagnostic technique for the diagnosis of membranous nephropathy.
View Article and Find Full Text PDFRational Design of Quinoxalinone-Based Red-Emitting Probes for High-Affinity and Long-Term Visualizing Amyloid-β In Vivo.
Anal Chem
May 2022
Key Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu 610064, People's Republic of China.
Alzheimer's disease (AD) is a progressive neurodegenerative disease with insidious onset, and the deposition of amyloid-β (Aβ) is believed to be one of the main cause. Fluorescence imaging is a promising technique for this task, but the Aβ gold standard probe ThT developed based on this still has shortcomings. The development of a new fluorescent probe to detect Aβ plaques is thought to be essential.
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