To understand the impact of different types of polyphenol-starch complexes on digestibility and gut microbiota, caffeic acid (CA) and corn starch (CS) complexes were prepared by coheating and high-pressure homogenization. The resistant starch content in CS coheated with CA (HCS-CA) and HCS-CA after high-pressure homogenization (HCS-CA-HPH) was 47.75 and 56.65%, respectively. Fourier transform infrared spectroscopy and X-ray diffraction analysis revealed hydrogen bonding in coheated samples and enhanced V-complex formation with high-pressure homogenization. The -digested complexes were of the B + V type, with higher relative crystallinity and short-range ordering of HCS-CA-HPH. Fermentation of the digested complex with human feces increased the yield of acetate, butyrate, and total short-chain fatty acids (SCFAs), which was more pronounced for HCS-CA-HPH. HCS-CA increased abundance, while HCS-CA-HPH boosted , , , and . Overall, CA and CS complexes enhanced beneficial bacteria and increased SCFA production.
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http://dx.doi.org/10.1021/acs.jafc.4c06946 | DOI Listing |
Alzheimers Dement
December 2024
Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, 2007, NSW, Australia.
Background: Alzheimer's Disease (AD) poses a substantial global health burden, necessitating innovative therapeutic strategies. This study investigates the neuroprotective potential of a chrysin-loaded Nanostructured Lipid Carrier (NLC) drug delivery system in AD management. Employing the high-pressure homogenization method, chrysin-loaded NLCs were meticulously formulated to optimize drug delivery efficiency.
View Article and Find Full Text PDFChemMedChem
January 2025
Institute of Himalayan Bioresource Technology CSIR, Dietetics & Nutrition Technology Division, Palampur, 176061, Palampur, INDIA.
Gemcitabine (GEM), a chemotherapeutic agent, is widely utilized in treating various neoplasm conditions, such as pancreatic, lung, breast, and ovarian cancers. However, its therapeutic effectiveness is often hindered by its hydrophilic nature, short half-life and susceptibility to enzymatic degradation. To address these limitations, in this research, five new prodrugs of GEM were synthesized by conjugating its N-4 amino group with five different acids [4-decenoic acid (4Dec), lipoic acid (Lipo), lauric acid (Laur), 5-benzyl N-(tert-butoxycarbonyl)- L-glutamate (Glu), and decanoic acid (Dec)].
View Article and Find Full Text PDFPharmaceutics
December 2024
Department of Pharmaceutical Sciences, College of Pharmacy, QU Health Sector, Qatar University, Doha 2713, Qatar.
Background/objectives: This study aimed to fabricate, optimize, and characterize nanostructured lipid carriers (NLCs) loaded with trans-resveratrol (TRES) as an anti-cancer drug for pulmonary drug delivery using medical nebulizers.
Methods: Novel TRES-NLC formulations (F1-F24) were prepared via hot, high-pressure homogenization. One solid lipid (Dynasan 116) was combined with four liquid lipids (Capryol 90, Lauroglycol 90, Miglyol 810, and Tributyrin) in three different ratios (10:90, 50:50, and 90:10 /), with a surfactant (Tween 80) in two different concentrations (0.
Polymers (Basel)
December 2024
Department of Prosthodontics, Medical University of Warsaw, 02-097 Warsaw, Poland.
Incorporating nanoparticles into denture materials shows promise for the prevention of denture-associated fungal infections. This study investigates the antifungal properties of acrylic modified with microwave-sintered ZnO-Ag nanoparticles. ZnO-Ag nanoparticles (1% and 2.
View Article and Find Full Text PDFMicroorganisms
December 2024
Department of Agricultural and Food Sciences, Campus of Food Science, Alma Mater Studiorum, University of Bologna, Piazza Goidanich 60, 47521 Cesena, Italy.
Components of yeast cell walls, such as β-glucans and mannoproteins, show promise for developing sustainable biopolymers for food packaging. Efficient extraction, however, is challenging due to the complexity of the yeast cell wall. This study explored high-pressure homogenisation (HPH) and pulsed electric fields (PEFs), alone and with heat treatment (TT), on bakery yeast (BY) and brewery spent yeast (BSY) biomasses.
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