Objective: The aim of the study is to test the feasibility of an immediate-fit, adjustable prosthesis (iFIT Prosthesis) for persons with limb loss in Botswana.
Design: As part of the University of Pennsylvania and University of Botswana's long-term partnership, 18 persons with limb loss were fit at four different locations in Botswana. Patients were followed for 4-9 mos after fitting with an interview and Prosthetic Comfort and Utility questionnaire.
Results: Out of 18 participants, 13 were located and provided follow-up feedback. Seven of the original 13 were still wearing the adjustable socket, while three reverted to their old socket and three did not use any socket. The highest positive rated question was the ability of the socket to accommodate changes in volume. Twelve (92%) of the participants said that they would recommend the system, yet cited that bulk and lack of cosmetic cover as major issues. For participants who had a conventional prosthesis, it took over a year to get their device through prosthetists using conventional fabrication techniques.
Conclusions: This socket system seems to be a feasible option for persons with lower limb loss in Botswana. To address the issues raised by participants and enhance user acceptance, the immediate-fit, adjustable system should become less bulky and include a cosmetic cover.
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http://dx.doi.org/10.1097/PHM.0000000000002536 | DOI Listing |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11649006 | PMC |
Sci Rep
December 2024
College of Sports, Beihua University, Jilin, 132000, China.
In order to eliminate the impact of camera viewpoint factors and human skeleton differences on the action similarity evaluation and to address the issue of human action similarity evaluation under different viewpoints, a method based on deep metric learning is proposed in this article. The method trains an automatic encoder-decoder deep neural network model by means of a homemade synthetic dataset, which maps the 2D human skeletal key point sequence samples extracted from motion videos into three potential low-dimensional dense spaces. Action feature vectors independent of camera viewpoint and human skeleton structure are extracted in the low-dimensional dense spaces, and motion similarity metrics are performed based on these features, thereby effectively eliminating the effects of camera viewpoint and human skeleton size differences on motion similarity evaluation.
View Article and Find Full Text PDFBiomimetics (Basel)
December 2024
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
This study develops biomimetic strategies for slip prevention in prosthetic hand grasps. The biomimetic system is driven by a novel slip sensor, followed by slip perception and preventive control. Here, we show that biologically inspired sensorimotor pathways can be restored between the prosthetic hand and users.
View Article and Find Full Text PDFClin Genet
December 2024
IBMC-Institute for Molecular and Cell Biology, i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Hereditary spastic paraplegias (HSP) are a diverse group of neurodegenerative diseases characterized by lower limb spasticity and weakness. To date, over 80 genes have been associated with HSP, but many families remain without a molecular diagnosis. In this study, linkage analysis and whole-exome sequencing (WES) were performed to identify the causal gene in a HSP family with autosomal recessive inheritance.
View Article and Find Full Text PDFEur J Vasc Endovasc Surg
December 2024
Clinical Effectiveness Unit, Royal College of Surgeons of England, London, UK; Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK.
Objective: Major amputation and death are significant outcomes after lower limb revascularisation for chronic limb threatening ischaemia (CLTI), but there is limited evidence on their association with the timing of revascularisation. The aim of this study was to examine the relationship between time from non-elective admission to revascularisation and one year outcomes for patients with CLTI.
Methods: This was an observational, population based cohort study of patients aged ≥ 50 years with CLTI admitted non-electively for infra-inguinal revascularisation procedures in English NHS hospitals from January 2017 to December 2019 recorded in the Hospital Episode Statistics database.
J Biol Chem
December 2024
Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, K7L 3N6, Canada. Electronic address:
Calpain-3 is an intracellular Ca-dependent cysteine protease abundant in skeletal muscle. Loss-of-function mutations in its single-copy gene cause a dystrophy of the limb-girdle muscles. These mutations, of which there are over 500 in humans, are spread all along this 94-kDa multi-domain protein that includes three 40+-residue sequences (NS, IS1, and IS2).
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