AI Article Synopsis
- Exosomes are small vesicles (50-150 nm) that originate from multivesicular endosomes and are important for transferring proteins, lipids, and nucleic acids between cells, facilitating cell communication.
- RUBCN/rubicon has been identified as a regulator of exosome secretion by assisting in the endosomal recruitment of WIPI2, which enhances MVB formation through ESCRT.
- The study indicates that RUBCN is crucial for the age-related increase in exosome production, which carries pro-senescent microRNAs that accelerate cellular aging in recipient cells.
Article Abstract
Exosomes are small extracellular vesicles (EVs), which have the diameter of 50-150 nm and originate from intralumenal vesicles in multivesicular endosomes (MVBs). Exosomes secreted from donor cells are delivered to recipient cells for transferring of exosome cargos, such as proteins, lipids and nucleic acids. The cargo transfer by exosomes has a pivotal role in cell-to-cell communication for many cellular processes; however, the detailed mechanism remains largely elusive. In our recent study, we found that RUBCN/rubicon regulates exosome secretion through endosomal recruitment of WIPI2, which promotes ESCRT-dependent MVB formation. We further showed that this pathway is essential for age-dependent increasing of exosomes, which transfer the pro-senescent microRNAs, including and , and accelerate cellular senescence in the recipient cells. Our findings highlight RUBCN's key role in exosome secretion and its impact on cellular senescence, providing insights into its potential contributions to aging.
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| http://dx.doi.org/10.1080/15548627.2024.2437653 | DOI Listing |
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