Sargen and Helaine discover a prophage competition element in Salmonella that inhibits the lytic cycle of co-resident prophages by cleaving a subset of cellular tRNAs. During Salmonella pathogenesis in macrophages, a persister subset experiences prophage induction and competition, reducing release of immunogenic cellular components and altering macrophage response to infection.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.chom.2024.11.011 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Analysis of the Distribution Pattern and Prophage Types in Asiaticus 'Cuimi' Kumquat.
Plants (Basel)
December 2024
National-Local Joint Engineering Laboratory of Citrus Breeding, Cultivation/Horticulture Research Institute, Sichuan Academy of Agricultural Sciences, Chengdu 610066, China.
The 'Cuimi' kumquat is a unique citrus cultivar known for its thin, crisp pulp and sweet, aromatic flavor. In addition to its use in fresh consumption and processing, this variety exhibits certain medicinal properties. This study aims to investigate the genetic diversity of the Huanglongbing (HLB) bacterium across different tissues of the 'Cuimi' kumquat, offering a theoretical basis for understanding the HLB epidemic in Dechang County, Sichuan.
View Article and Find Full Text PDFInsights into the dynamics and evolution of Rummeliibacillus stabekisii prophages in extreme environments: from Antarctic soil to spacecraft floors.
Extremophiles
December 2024
Laboratório de Ecologia E Biotecnologia Microbiana, Instituto de Microbiologia Paulo de Góes, Centro de Ciências da Saúde, Universidade Federal Do Rio de Janeiro (UFRJ), Bloco I, Rio de Janeiro (RJ), Brazil.
Since prophages can play a multifaceted role in bacterial evolution, this study aims to characterize the virome of Rummeliibacillus stabekisii, a bacterium isolated from different environments, including Antarctic soil and NASA spacecraft floors. From the analyses, it was found that the Antarctic strain, PP9, had the largest number of prophages, including intact ones, indicating potential benefits for survival in adverse conditions. In contrast, other strains harbored predominantly degenerate prophages, suggesting a dynamic process of gene gain and loss during evolution.
View Article and Find Full Text PDFThe bad neighbor: Prophage competition in Salmonella during macrophage infection.
Cell Host Microbe
December 2024
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA. Electronic address:
Sargen and Helaine discover a prophage competition element in Salmonella that inhibits the lytic cycle of co-resident prophages by cleaving a subset of cellular tRNAs. During Salmonella pathogenesis in macrophages, a persister subset experiences prophage induction and competition, reducing release of immunogenic cellular components and altering macrophage response to infection.
View Article and Find Full Text PDFEvolution of virulence in emerging epidemics: from theory to experimental evolution and back.
Virus Evol
October 2024
CEFE, Univ Montpellier, CNRS, EPHE, IRD, Montpellier, France.
Article Synopsis
- The study focuses on improving the quantitative validation of theoretical models in infectious disease dynamics, particularly for a polymorphic viral population.
- It details an experiment involving a temperate bacteriophage to assess how epidemiological dynamics affect virus transmission and virulence.
- The findings highlight the importance of directly modeling infected bacterial cells to enhance fit with experimental data, and introduce estimations for key traits of the viral strains, ultimately enriching our understanding of the phage's evolutionary epidemiology.
The antibacterial activity of a prophage-encoded fitness factor is neutralized by two cognate immunity proteins.
J Biol Chem
December 2024
Michael DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada. Electronic address:
The human gastrointestinal tract is a competitive environment inhabited by dense polymicrobial communities. Bacteroides, a genus of Gram-negative anaerobes, are prominent members of this ecological niche. Bacteroides spp.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!