The sensing of pathogens is the first step for any immune response. A recent paper in Cell reveals that the bacterial Hachiman anti-phage defense system deploys a helicase subunit to sense phage invasion via 3' DNA recognition and subsequent domain rotation to enable nuclease activation.
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| http://dx.doi.org/10.1016/j.chom.2024.11.009 | DOI Listing |
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