The octopus has attracted widespread attention owing to its unique underwater movement and its ability to escape with inkjets, which also promoted the development of underwater bionic robots. This study introduces a magnetic octopus robot (MOR) 3D printed with PA6/NdFeB composite material, which has good magnetic responsiveness and rigidity to cope with complex environments. The MOR can roll and rotate through complex terrain and passages because of its eight-claw structure. It also has amphibious locomotion and can pass through narrow gaps of 37.5% of its height by deformation. In addition, the MOR can not only clamp, transport, and release solids but also liquids by adding silicone hollow spheres, which indicates the potential of the MOR to be used in medical applications for transporting solid or liquid drugs. This research will help broaden the application prospects of magnetron robots in the field of medical drug transportation.
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http://dx.doi.org/10.1089/soro.2023.0055 | DOI Listing |
Front Biosci (Landmark Ed)
December 2024
Department of Biochemistry, Cell Biology and Microbiology, Mari State University, 424001 Yoshkar-Ola, Russia.
Objective: Ca overload of muscle fibers is one of the factors that secondarily aggravate the development of Duchenne muscular dystrophy (DMD). The purpose of this study is to evaluate the effects of the Ca channel modulator 2-aminoethoxydiphenyl borate (APB) on skeletal muscle pathology in dystrophin-deficient mice.
Methods: Mice were randomly divided into six groups: wild type (WT), WT+3 mg/kg APB, WT+10 mg/kg APB, , +3 mg/kg APB, +10 mg/kg APB.
Oncol Res
December 2024
School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland (RCSI), Dublin, D02 YN77, Ireland.
Brain metastasis and primary glioblastoma multiforme represent the most common and lethal malignant brain tumors. Its median survival time is typically less than a year after diagnosis. One of the major challenges in treating these cancers is the efficiency of the transport of drugs to the central nervous system.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
December 2024
Recordati Rare Diseases, Central and Eastern Europe, Warsaw, Poland.
Pasireotide is an effective treatment for both Cushing's disease (CD) and acromegaly due to its ability to suppress adrenocorticotropic hormone and growth hormone, and to normalize insulin-like growth factor-1 levels, resulting in tumor shrinkage. However, it may also cause hyperglycemia as a side effect in some patients. The aim of this study was to review previous recommendations regarding the management of pasireotide-induced hyperglycemia in patients with CD and acromegaly and to propose efficient monitoring and treatment algorithms based on recent evidence and current guidelines for type 2 diabetes treatment.
View Article and Find Full Text PDFPart Fibre Toxicol
December 2024
Division of Cardiology, David Geffen School of Medicine, University of California-Los Angeles, 10833 Le Conte Avenue, CHS 43-264, P.O. Box 951679, Los Angeles, CA, 90095, USA.
Background: Exposure to air pollution is associated with worldwide morbidity and mortality. Diesel exhaust (DE) emissions are important contributors which induce vascular inflammation and metabolic disturbances by unknown mechanisms. We aimed to determine molecular pathways activated by DE in the liver that could be responsible for its cardiometabolic toxicity.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China; Key Laboratory of Agro-Products Quality and Safety Control in Storage and Transport Process, Ministry of Agriculture and Rural Affairs, Chinese Academy of Agricultural Sciences, Beijing 100193, China; Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address:
The development of functional hydrogel dressings with robust mechanical properties has posed a significant challenge in expediting the healing process of MRSA-infected wounds. To address this, a composite hydrogel, comprising carboxylated soybean cellulose nanocrystals (CNCs), poly(N-isopropyl acrylamide) (PNIPAM), dimethyl diallyl ammonium chloride (PDADMAC), and kaolin (CN/P-K) was synthesized. CNCs served to stabilize the interpenetrating polymer networks of PNIPAM and PDADMAC through hydrogen bonding and electrostatic interactions, respectively, while the kaolin interlayer improved the material toughness.
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