Falsifiable research is a basic goal of science and is needed for science to be self-correcting. However, the methods for conducting falsifiable research are not widely known among psychological researchers. Describing the effect sizes that can be confidently investigated in confirmatory research is as important as describing the subject population. Power curves or operating characteristics provide this information and are needed for both frequentist and Bayesian analyses. These evaluations of inferential error rates indicate the performance (validity and reliability) of the planned statistical analysis. For meaningful, falsifiable research, the study plan should specify a minimum effect size that is the goal of the study. If any tiny effect, no matter how small, is considered meaningful evidence, the research is not falsifiable and often has negligible predictive value. Power ≥ .95 for the minimum effect is optimal for confirmatory research and .90 is good. From a frequentist perspective, the statistical model for the alternative hypothesis in the power analysis can be used to obtain a value that can reject the alternative hypothesis, analogous to rejecting the null hypothesis. However, confidence intervals generally provide more intuitive and more informative inferences than p values. The preregistration for falsifiable confirmatory research should include (a) criteria for evidence the alternative hypothesis is true, (b) criteria for evidence the alternative hypothesis is false, and (c) criteria for outcomes that will be inconclusive. Not all confirmatory studies are or need to be falsifiable. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
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http://dx.doi.org/10.1037/met0000639 | DOI Listing |
J Pers Soc Psychol
January 2025
Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine.
People who are higher in conscientiousness, extraversion, and agreeableness and lower in neuroticism tend to live longer. The present research tested the hypothesis that personality trait change in middle and older adulthood would also be associated with mortality risk, above and beyond personality trait level. Personality trait change may causally influence mortality risk through corresponding changes in health behaviors, social processes, and stress experience.
View Article and Find Full Text PDFJ Mol Cell Cardiol Plus
June 2024
Division of Pulmonary Circulation, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
Background: Pulmonary hypertension (PH) often leads to right ventricle (RV) failure, a significant cause of morbidity and mortality. Despite advancements in PH management, progression to RV maladaptation and subsequent failure remain a clinical challenge. This study explored the effect of paroxetine, a selective serotonin reuptake inhibitor (SSRI), on RV function in a rat model of PH, hypothesizing that it improves RV function by inhibiting G protein-coupled receptor kinase 2 (GRK2) and altering myofilament protein phosphorylation.
View Article and Find Full Text PDFPsychol Belg
January 2025
Department of Data-Analysis, Ghent University, Belgium.
Performing hypothesis tests with adequate statistical power is indispensable for psychological research. In response to several large-scale replication projects following the replication crisis, concerns about the root causes of this crisis - such as questionable research practices (QRPs) - have grown. While initial efforts primarily addressed the inflation of the type I error rate of research due to QRPs, recent attention has shifted to the adverse consequences of low statistical power.
View Article and Find Full Text PDFEnviron Pollut
January 2025
CESAM - Centre for Environmental and Marine Studies, Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal.
Corrosion significantly affects the maritime industry. To address this issue, corrosion inhibitors are incorporated into polymeric coatings. However, some state-of-the-art inhibitors are toxic, prone to spontaneous leaching, and interact with coating components.
View Article and Find Full Text PDFClin Nutr ESPEN
January 2025
University of Medical Sciences, Department of Histology and Embryology, Poznań, Poland.
Background & Aims: The developmental origin of health and disease hypothesis shows that early adverse exposures can have lifelong health effects. Thus, the aim of this study was to analyze the impact of choline intake during pregnancy and/or lactation on gene expression profiles in the liver of 24-day-old male rat offspring from dams with non-alcoholic fatty liver disease (NAFLD).
Methods: Phenotypic characteristic, histological examination and global transcriptome pattern of liver tissue specimens obtained from offspring of dams suffering from fatty liver, provided with proper choline intake during pregnancy and lactation (NN), fed a choline-deficient diet during both periods (DD), deprived of choline only during pregnancy (DN), or only during lactation (ND), was performed.
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