The sticky business of Alphavirus capsid-host interactions.

Trends Microbiol

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address:

Published: December 2024

AI Article Synopsis

  • Alphaviruses pose a significant threat to global health, causing serious diseases in both humans and animals, and there are currently no approved antiviral treatments.
  • This review emphasizes the importance of understanding the alphavirus capsid protein, which has known roles in virus assembly but lesser-known interactions with host cell proteins.
  • Recent findings reveal new potential interactions between the capsid and host proteins, shedding light on how the capsid may help the virus evade immune responses and outlining challenges and opportunities for future research.

Article Abstract

Alphaviruses are a serious threat to global health and can cause lethal encephalitic or arthritogenic disease in humans and animals. As there are no licensed antivirals, it is critical to improve our understanding of alphavirus interactions with the host cell. Here, we focus on the essential alphavirus protein capsid. While its roles in genome packaging and virus assembly have been wellstudied, much less is known about capsid's interactions with host proteins and their functional relevance for infection. Recently, several new capsid interactor candidates were identified, collectively emphasising the complexity of capsid-host biology. In this review we summarise these novel interactor candidates, highlight capsid's emerging role in immune evasion, and discuss the challenges and opportunities arising from capsid-host interactions.

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http://dx.doi.org/10.1016/j.tim.2024.11.003DOI Listing

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  • Recent findings reveal new potential interactions between the capsid and host proteins, shedding light on how the capsid may help the virus evade immune responses and outlining challenges and opportunities for future research.
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