AI Article Synopsis
- Researchers are focused on developing new chiral pharmaceutical candidates, which requires innovative synthetic chemistry techniques.
- Achieving diverse and efficient construction of molecular structures with multiple chiral centers is a major objective in the field.
- The introduction of a new method, asymmetric chain-walking arylation, allows for the effective creation of multiple chiral centers in compounds, showing promise for future industrial applications.
Article Abstract
Exploration of novel chiral pharmaceutical candidates is motivation to immersive efforts among synthetic chemists. Achieving skeletal construction and chiral diversity in a highly efficient manner is a momentous goal in the chemical society. Unfortunately, current methods for chiral induction focus primarily on a specific site. Herein, we realized the asymmetric chain-walking arylation of alkenyl alcohols for the construction of multisite tertiary and quaternary stereocenters in high yields and enantioselectivity. This new operation-friendly strategy carries substantial potential for future industrialization.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665887 | PMC |
| http://dx.doi.org/10.1073/pnas.2408541121 | DOI Listing |
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