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Commentary on "Testis tissue cryopreservation may be considered in boys with cryptorchidism".
Asian J Androl
December 2024
Institute for Cryptorchidism Research, Bahnhof Platz 11, Liestal 4410, Switzerland.
Revisiting the specific and potentially independent role of the gonad in hormone regulation and reproductive behavior.
J Exp Biol
November 2024
Department of Evolution, Ecology, and Behavior, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Gonadal sex steroid hormones are well-studied modulators of reproductive physiology and behavior. Recent behavioral endocrinology research has focused on how the brain dynamically responds to - and may even produce - sex steroids, but the gonadal tissues that primarily release these hormones receive much less attention as a potential mediator of behavioral variation. This Commentary revisits mechanisms by which the reproductive hypothalamic-pituitary-gonadal (HPG) axis can be modulated specifically at the gonadal level.
View Article and Find Full Text PDFValidation of the Online Collaborative Ocular Tuberculosis Study Calculator for Tubercular Uveitis.
JAMA Ophthalmol
December 2024
Lee Kong Chian School of Medicine, Nanyang Technological University of Singapore.
Article Synopsis
- This study is the first of its kind to statistically assess how well the Collaborative Ocular Tuberculosis Study (COTS) calculator predicts the need for antitubercular therapy (ATT) in patients with suspected tubercular uveitis (TBU) in an international setting.
- The main goal was to determine if a score of 4 or higher on the COTS calculator effectively guides the initiation of ATT.
- Results showed that among 492 participants, 45.7% received a high probability for ATT initiation, and the COTS-5 score showed the highest specificity at 88.7%, suggesting its effectiveness compared to clinician judgment.
Response to commentary: "Experimental study of the effectiveness of warm ischemia and cold ischemia during testis-sparing surgery in rats".
J Pediatr Urol
October 2024
University of Health Sciences Turkey, Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Department of Pediatric Surgery, Ankara, Turkey. Electronic address:
PIWI-interacting RNAs: who, what, when, where, why, and how.
EMBO J
November 2024
Department of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland.
PIWI-interacting RNAs (piRNA) suppress selfish genetic elements and are essential for germ cell biology in animals. They also play critical roles in regeneration in planaria, regulate gene expression in adult mammalian testes, and participate in antiviral defense in mosquitoes. Inspired by a recent workshop on PIWI proteins and piRNAs, this commentary aims to summarize fundamental aspects of piRNA biology, highlight recent advances, and discuss key outstanding questions.
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