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Article Synopsis
  • A 67-year-old African American male, diagnosed with "schizophrenia, unspecified," was referred to psychiatry due to auditory and visual hallucinations that began two years after starting Norco for chronic back pain.
  • The patient noted that his hallucinations worsened with increased Norco dosage but disappeared when he stopped taking the medication.
  • The case underscores the risk of misdiagnosing opioid-induced hallucinations as schizophrenia and stresses the need for thorough assessments of opioid use in patients with psychiatric symptoms.
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Implications of the choroid plexus in Niemann-Pick disease Type C neuropathogenesis.

Brain Behav Immun

December 2024

Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA. Electronic address:

Background: Niemann-Pick Disease Type C (NPC) is an ultra-rare disorder characterized by progressive psychiatric and neurologic manifestations, with late infantile, juvenile, and adolescent/adult presentations. We examined morphological properties of the choroid plexus, a protective blood-cerebrospinal fluid barrier, in NPC, and their relationship with neurodegeneration, clinical status, and circulatory markers. This study also determined whether choroid plexus morphology differentiates between NPC and more prevalent illnesses, schizophrenia (SZ) and bipolar disorder (BD), which have overlapping psychiatric symptoms with adolescent and adult-onset NPC and are associated with misdiagnosis.

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Mental health disorders are devastating illnesses, often misdiagnosed due to overlapping clinical symptoms. Among these conditions, bipolar disorder, schizophrenia, and schizoaffective disorder are particularly difficult to distinguish, as they share alternating positive and negative mood symptoms. Accurate and timely diagnosis of these diseases is crucial to ensure effective treatment and to tailor therapeutic management to each individual patient.

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Cultural Competemility Training and Use of a Standardized Assessment Tool in Reducing Misdiagnosis of Black Patients with Schizophrenia Spectrum Disorders and Psychotic Disorders.

J Am Psychiatr Nurses Assoc

November 2024

Josepha Campinha-Bacote, PhD, MAR, PMHCNS-BC, CTN-A, FAAN, FTNSS, President, Transcultural C.A.R.E. Associates, Cincinnati, OH, USA.

Introduction: Research studies have highlighted disparities in diagnosing schizophrenia between Black and White patients, with Black individuals being diagnosed at rates three to five times higher than their White counterparts. Moreover, studies have postulated that a lack of cultural awareness and biases leads to providers' misinterpretation and misdiagnosis of these patients.

Aims: This quality-improvement project aimed (a) to enhance cultural competemility, the synergistic process between cultural humility and cultural competence in health care providers (HCPs) serving Black patients, promoting cultural sensitivity among providers serving all patients; (b) to introduce the Brief Psychiatric Rating Scale (BPRS-24) as a standardized tool for evaluating suspected schizophrenia spectrum disorders and psychotic disorders across all patients; and (c) to reduce the disparities in schizophrenia spectrum disorders and psychosis diagnostic rates across all patients, with a focus on enhancing accuracy for Black patients.

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